MO086THE EFFECT OF HIGH SODIUM CHLORIDE INTAKE ON CARDIOVASCULAR SYSTEM AND KIDNEYS IN SPONTANEOUSLY HYPERTENSIVE RATS. (29th May 2021)

• Record Type: Journal Article
• Authors: Kayukov,, Ivan; Beresneva, Olga; Parastaeva, Marina; Ivanova, Galina; Zaraiski, Mikhail; Kucher, Anatoly; Smirnov, Kirill; Khasun, Mokhamad; Smirnov, Alexei
• Is Part Of: Nephrology dialysis transplantation. Volume 36(2021)Supplement 1
• Publication Date: 2021-05-29
• Subjects: Nephrology -- Periodicals; Hemodialysis -- Periodicals; Kidneys -- Transplantation -- Periodicals; Hemodialysis; Kidneys -- Transplantation; Nephrology; Periodicals; 616.61
• DOI: 10.1093/ndt/gfab078.0022
• Languages: English
• ISSNs: 0931-0509

Abstract

Abstract: Background and Aims: It is believed that high consumption of sodium chloride (NaCl) leads to the development of arterial hypertension, which result in heart remodeling, however, NaCl can probably cause direct heart damage. We aimed to evaluate the effects of high and normal NaCl containing diets on blood pressure (BP), myocardial remodeling, as well as on the level of nuclear transcription factor κB (NFκB) expression in myocardium and kidneys. Method: 49 spontaneously hypertensive rats (SHR) were enrolled and subdivided into 2 groups: Group 1 (n=24) received standard diet (NaCl=0, 34%); Group 2 (n=25) was on high sodium diet (NaCl=8%). In 2 months, systolic BP, myocardial and renal mass indices, morphological changes, as well as NFκB expression in heart and kidneys were assessed. Results are presented as mean ± SD. Results: BP in group 2 did not change significantly (190 ± 10 mm Hg, p> 0.05) compared to group 1, yet left ventricle muscle mass indices as well as, right and left kidney mass indices were higher. Hypertrophy of cardiomyocytes (CMC) was found in group2: (area of the nucleus- 43.55 ± 17.39 μm2 (p <0.001); area of CMC-21799.31 ± 579.89 μm2 (p <0.001), compared to group 1: (area of the nucleus- 36.14 ± 4.67 μm2 (p <0.001); area of CMC-19011.13 ± 571.8 μm2 (p <0.001). Also, perivascular fibrosis was found in group2 (area of perivascular connective tissue(APCT)- 4038.96 ± 28.58 μm2 (p <0.001), compared to group1 (APCT-3718.36 ± 91.8 μm2, p <0.001). An increase in arterial wall thickness was noted in group 2 (15.71 ± 6.28 μm, p<0, 001), compared to group 1 (13.51 ± 8, 68 μm, p<0, 001). The expression level of NFκB in myocardial tissue (n = 7) in group 2 was 33 times higher, and in kidney tissue (n = 5) 12 times higher than in group 1 (n = 8). Conclusion: High consumption of NaCl induces NFκB activation in kidneys and myocardium, and may cause myocardial remodeling, probably via NFκB - associated signaling pathways.