Polarized transport of membrane and secreted proteins during lumen morphogenesis. (15th January 2023)

• Record Type: Journal Article
• Authors: Levic, Daniel S.; Bagnat, Michel
• Is Part Of: Seminars in cell & developmental biology. Volume 133(2023)
• Page Start: 65
• Page End: 73
• Publication Date: 2023-01-15
• Subjects: ABCC4 ATP Binding Cassette Subfamily C Member 4 -- AJ Adherens Junction -- AMIS Apical Membrane Initiation Site -- Anxa2 Annexin A2 -- AP Adaptor Protein -- aPKC Atypical Protein Kinase C -- cAMP Cyclic Adenosine Monophosphate -- CDC42 Cell Division Cycle 42 -- CD34 CD34 Molecule -- CFTR Cystic Fibrosis Transmembrane Conductance Regulator -- CG5789 Drosophila Dmel\CG5789 -- CHEs CFTR High Expressing Cells -- Ch-LD Chitin-binding, Low-Density Lipoprotein Particle Receptor Class A-containing deacetylase -- CHO Chinese Hamster Ovary -- Cldn15la Claudin15-like A -- COP-1 Coat Protein 1 -- Cse1l Chromosome Segregation 1 Like -- ECM Extracellular Matrix -- Ehbp1 EH Domain Binding Protein 1 -- ER Endoplasmic Reticulum -- GEF Guanine Exchange Factor -- GPI Glycosylphosphatidylinositol -- KV Kupffer's Vesicle -- MDCK Madin-Darby Canine Kidney -- Na+/K+-ATPase Sodium-Potassium Pump -- NHERF1 Na(+)/H(+) Exchange Regulatory Cofactor NHE-RF1 -- Nkcc1 Sodium-Potassium-Chloride Cotransporter 1 -- Par3 Partitioning Defective 3 Homolog -- Par6 Partitioning Defective 6 Homolog -- PDZ PSD-95, Disks Large, Zona Occludens 1 -- PDZK1 PDZ Domain Containing 1 -- PKA Protein Kinase 1 -- SJ Septate Junction -- SMG Submandibular Gland -- Tcf2 Transcription Factor 2 -- TGN Trans-Golgi Network -- VIP Vasoactive Intestinal Peptide -- V-H+ ATPase Vacuolar-Proton ATPase -- VIPR1 Vasoactive Intestinal Peptide Receptor 1 -- ZO-1 Zona Occludens 1; Lumen -- Epithelial -- Polarity -- Fluid secretion -- Morphogenesis -- Zebrafish; Cytology -- Periodicals; Developmental biology -- Periodicals; 571.6
• DOI: 10.1016/j.semcdb.2022.03.016
• Languages: English
• ISSNs: 1084-9521

Abstract

Abstract: A ubiquitous feature of animal development is the formation of fluid-filled cavities or lumina, which transport gases and fluids across tissues and organs. Among different species, lumina vary drastically in size, scale, and complexity. However, all lumen formation processes share key morphogenetic principles that underly their development. Fundamentally, a lumen simply consists of epithelial cells that encapsulate a continuous internal space, and a common way of building a lumen is via opening and enlarging by filling it with fluid and/or macromolecules. Here, we discuss how polarized targeting of membrane and secreted proteins regulates lumen formation, mainly focusing on ion transporters in vertebrate model systems. We also discuss mechanistic differences observed among invertebrates and vertebrates and describe how the unique properties of the Na + /K + -ATPase and junctional proteins can promote polarization of immature epithelia to build lumina de novo in developing organs.