A study of the reactivity of cyclic aminomethylammonium mannich salts. (3rd December 2022) - Dimitrova, Daniela
Abstract: A novel method for the preparation of aminoalkylaminomethyl products was developed utilising novel Mannich-type salts featuring a R2 NCH2 NR3 + moiety. This methodology showed good nucleophile scope and was successfully employed in reactions under basic, acidic, and neutral conditions. A wide range of diamine products was successfully synthesised, including a neuropeptide Y antagonist. Graphical abstract: Image 1