Two novel isoflavone derivatives from Ficus esquiroliana Levl. and their cytotoxic effects on cancer cells. (December 2022)

• Record Type: Journal Article
• Authors: Dai, De-Cai; Xu, Xue-Feng; Yan, Hao; Zhang, Yu
• Is Part Of: Phytochemistry letters. Volume 52(2022)
• Page Start: 45
• Page End: 48
• Publication Date: 2022-12
• Subjects: Moraceae -- Ficus esquiroliana Levl. -- Isoflavone derivatives -- Ficusavone -- Cytotoxic activity; Botanical chemistry -- Periodicals; Chimie végétale -- Périodiques; 572.205
• DOI: 10.1016/j.phytol.2022.09.003
• Languages: English
• ISSNs: 1874-3900

Abstract

Abstract: Two novel isoflavone derivatives ficusavone A and B (1 and 2 ) together with two known biogenetically related isoflavone derivatives (3 and 4 ) were isolated from the stems of Ficus esquiroliana Levl. The structures of these compounds were elucidated using comprehensive spectroscopic methods. Compounds 1 and 2 represent the rare example of an isoflavone derivative of oxidative cracking of isopentene from natural products. The inhibitory activities of all compounds against HeLa, MCF-7 and A549 cells were evaluated. Compound 1 showed the cytotoxicity against the MCF-2 (IC50 = 12.3 μ M) and A549 (IC50 = 17.8 μ M) cell lines. The other compounds showed modest activities or were inactive. Graphical Abstract: ga1 Highlights: A phytochemical study of Ficus esquiroliana EtOH extract was carried out. Two novel isoflavone derivatives ficusavone A and B were isolated and characterized. Compound 1 showed the cytotoxicity against the MCF-2 (IC50 = 12.3 μ M) and A549 (IC50 = 17.8 μ M) cell lines.