1, 3-dichloro-5, 5-dimethylhydantoin promoted esterification of carboxylic acids under mild conditions. (7th December 2022)

• Record Type: Journal Article
• Authors: Dong, Qing; Huang, Qingqiu; Wang, Mengke; Chen, Hongyan; Zi, You; Huang, Weichun
• Is Part Of: Tetrahedron letters. Volume 112(2022)
• Publication Date: 2022-12-07
• Subjects: Esterification -- Carboxylic acid -- Alcohol -- Ester -- 1, 3-Dichloro-5, 5-dimethylhydantoin; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2022.154226
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: A novel and practical method has been discovered for the synthesis of esters from carboxylic acids promoted by 1, 3-Dichloro-5, 5-dimethylhydantoin. Reactions proceed smoothly under mild conditions and show high efficiency with good to excellent yields. Abstract: A novel and practical method has been discovered for the synthesis of esters from carboxylic acids promoted by 1, 3-dichloro-5, 5-dimethylhydantoin. Reactions proceed smoothly under mild conditions and show high efficiency with good to excellent yields. A series of carboxylic acids including simple molecules, drugs and amino acids are applicable to this method.