Identification of a novel cardiac epitope triggering T-cell responses in patients with myocardial infarction. (December 2022)

• Record Type: Journal Article
• Authors: Hapke, Nils; Heinrichs, Margarete; Ashour, DiyaaElDin; Vogel, Elena; Hofmann, Ulrich; Frantz, Stefan; Campos Ramos, Gustavo
• Is Part Of: Journal of molecular and cellular cardiology. Volume 173(2022)
• Page Start: 25
• Page End: 29
• Publication Date: 2022-12
• Subjects: Myocardial infarction -- T-cells -- Cardiac antigens -- HLA-DRB1*13 -- Adrenergic receptor beta-1; α-actin ACTC1 -- adrenergic receptor β1 ADRB1 -- coronary angiography CA -- creatine kinase CK -- creatine kinase-MB CK-MB -- fibrinogen α, β, and γ chains FGA, FGB, FGG -- heart failure HF -- heat shock protein family B3 HSPB3 -- human leukocyte antigen HLA -- interferon-gamma IFN-γ -- interleukin-2 IL-2 -- lactate dehydrogenase LDH -- myocardial infarction MI -- myosin-binding protein C3 MYBPC3 -- myosin heavy chain-α MYHCA -- myosin light chain-2 MYL2 -- non-ST-elevation myocardial infarction NSTEMI -- N-terminal pro-B-type natriuretic peptide NT-proBNP -- ST-elevation myocardial infarction STEMI -- T-cell receptor TCR -- troponin I3 TNNI3 -- troponin T2 TNNT2; Cardiology -- Periodicals; Heart Diseases -- Periodicals; Molecular Biology -- Periodicals; Cardiologie -- Périodiques; Cardiology; Electronic journals; Periodicals; 616.12
• DOI: 10.1016/j.yjmcc.2022.09.001
• Languages: English
• ISSNs: 0022-2828

Abstract

Abstract: T-cells contribute to pathophysiological processes in myocardial diseases, including myocardial infarction (MI) and heart failure (HF). Antigen-specificity is a hallmark of T-cell responses but the cardiac antigens that trigger heart-directed T-cell responses in patients have not yet been uncovered, thus posing a roadblock to translation. In the present exploratory study, we identified a peptide fragment of the beta-1 adrenergic receptor (ADRB1) that elicits CD4 + T-cell responses after myocardial infarction in patients with a defined HLA haplotype. Our observations may advance the development of tools to monitor other antigen-specific immune responses in patients. Graphical abstract: Unlabelled Image Highlights: The beta-1 adrenergic receptor (ADRB1) is an autoantigen source in MI patients. ADRB1167 – 182 triggers T-cell responses in HLA-DRB1*13 + MI patients. Cardiac epitope mapping may provide new tools to monitor post-MI T-cell responses. Further studies are needed to uncover the relevance of ADRB1− specific T-cells in MI.