Comparison of dorsal penile nerve block alone and in combination with lidocaine–prilocaine cream in neonates undergoing circumcision: a randomized controlled study. Issue 4 (17th November 2022)

• Record Type: Journal Article
• Authors: Ogundele, Ibukunolu Olufemi; Nwokoro, Chigbundu Collins; Adedeji, Tewogbade Adeoye; Igwe, Arua Obasi; Adumah, Collins Chijioke; Talabi, Ademola Olusegun; Shonubi, Aderibigbe Modupe; Sowande, Oludayo Adedapo
• Is Part Of: World journal of pediatric surgery. Volume 5:Issue 4(2022)
• Publication Date: 2022-11-17
• Subjects: Analgesia -- Anesthetics -- Neonatology -- Pain -- Pediatrics; Children -- Surgery -- Periodicals; 617.98
• DOI: 10.1136/wjps-2022-000470
• Languages: English
• ISSNs: 2516-5410

Abstract

Abstract : Background: Suboptimal neonatal circumcision analgesia causes a significant stress response. There is continued search for more effective analgesia for neonatal circumcision. We aimed to determine whether lidocaine–prilocaine cream (LPC) prior to dorsal penile nerve block (DPNB) offers better analgesia than DPNB alone. Methods: A prospective randomized study of 72 neonates undergoing plastibell circumcision was randomized into two groups of 36 each. Group I received DPNB alone with 4 mg/kg plain lidocaine. Group II had 1 g LPC applied to the phallus 1 hour before DPNB. Serum cortisol levels were measured 30 min preoperatively and 30 min postoperatively. Heart rate (HR) and peripheral arterial oxygen saturation (SpO2 ) were noted at 30 min preoperatively, after DPNB injection, after excising the prepuce, and at 30 min thereafter. The primary outcome measure was change in serum cortisol levels, while secondary outcomes were changes in HR and SpO2 . Results: Both groups had increased mean serum cortisol levels, decreased mean SpO2 and increased mean HR from baseline. The rise in mean serum cortisol level was significantly lower in group II (8.09±4.53 µg/dL) than that in group I (11.42±7.83 µg/dL) (p=0.034). Changes in SpO2 and HR were significantly less in group II than that in group I patients (p<0.05), except for HR changes at 30 min after excision of the prepuce (p=0.086). Conclusion: These data suggest that neonates who received LPC prior to DPNB experienced significantly less pain from plastibell circumcision than those who had DPNB alone. Trial registration number: PACTR201906554747665.