Animal models for epileptic foci localization, seizure detection, and prediction by electrical impedance tomography. Issue 6 (12th September 2022)

• Record Type: Journal Article
• Authors: Wang, Rong; Zhu, Wenjing; Liang, Guohua; Xu, Jiaming; Guo, Jie; Wang, Lei
• Is Part Of: Wiley interdisciplinary reviews. Volume 13:Issue 6(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-09-12
• Subjects: animal model -- chemical convulsants -- electrical impedance tomography -- physical stimulation -- refractory epilepsy; Cognitive science -- Periodicals; 153.05
• DOI: 10.1002/wcs.1619
• Languages: English
• ISSNs: 1939-5086

Abstract

Abstract: Surgical resection of lesions and closed‐loop suppression are the two main treatment options for patients with refractory epilepsy whose symptoms cannot be managed with medicines. Unfortunately, failures in foci localization and seizure prediction are constraining these treatments. Electrical impedance tomography (EIT), sensitive to impedance changes caused by blood flow or cell swelling, is a potential new way to locate epileptic foci and predict seizures. Animal validation is a necessary research process before EIT can be used in clinical practice, but it is unclear which among the many animal epilepsy models is most suited to this task. The selection of an animal model of epilepsy that is similar to human seizures and can be adapted to EIT is important for the accuracy and reliability of EIT research results. This study provides an overview of the animal models of epilepsy that have been used in research on the use of EIT to locate the foci or predict seizures; discusses the advantages and disadvantages of these models regarding inducement by chemical convulsant and electrical stimulation; and finally proposes optimal animal models of epilepsy to obtain more convincing research results for foci localization and seizure prediction by EIT. The ultimate goal of this study is to facilitate the development of new treatments for patients with refractory epilepsy. This article is categorized under: Neuroscience > Clinical Neuroscience Psychology > Brain Function and Dysfunction Abstract : The main treatment of refractory epilepsy is surgical resection of the focus, however, there are some limitations, can not completely inhibit seizures. As a new medical imaging technology, EIT is feasible in the localization of epileptic foci, detection and prediction of seizures. A suitable animal model is the basis of the research. This paper discusses the conditions of the animal epileptic model suitable for EIT, and provides an appropriate model selection for the application of EIT in the epileptic foci localization, seizure detection, and prediction.