Multiple Lytic Bone Lesions Mimicking Langerhans Cell Histiocytosis: A Case of Infantile Mendelian Susceptibility to Mycobacterial Disease due to STAT1 Deficiency. (11th October 2022)

• Record Type: Journal Article
• Authors: He, Yingyi; Zhang, Hui; Li, Chunjie; Su, Xiaoling; Gan, Wenting; Wang, Pengfei; Xiao, Weiqiang
• Is Part Of: Open forum infectious diseases. Volume 9:Number 11(2022)
• Publication Date: 2022-10-11
• Subjects: disseminated BCG disease -- STAT1 mutation -- Langerhans cell histiocytosis -- osteolytic lesions; Communicable diseases -- Periodicals; Medical microbiology -- Periodicals; Infection -- Periodicals; 616.9
• DOI: 10.1093/ofid/ofac533
• Languages: English
• ISSNs: 2328-8957

Abstract

Abstract: We present the first infantile disseminated Bacillus Calmette-Guérin (BCG) disease case with STAT1 deficiency, which is manifested by multiple Langerhans cell histiocytosis–like osteolytic lesions. The diagnosis of BCG-induced osteomyelitis was not initially considered until the additional biopsy revealing granulomatous inflammation, a key pathological diagnostic component for mycobacterial infection.