Dynamic contrast‐enhanced MRI and Doppler sonography in patients with squamous cell carcinoma of head and neck treated with induction chemotherapy. Issue 9 (7th October 2022)

• Record Type: Journal Article
• Authors: Chawla, Sanjeev; Loevner, Laurie; Mohan, Suyash; Lin, Alexander; Sehgal, Chandra M.; Poptani, Harish
• Is Part Of: Journal of clinical ultrasound. Volume 50:Issue 9(2022)
• Page Start: 1353
• Page End: 1359
• Publication Date: 2022-10-07
• Subjects: Doppler sonography -- dynamic contrast enhanced‐MRI -- head and neck squamous cell carcinoma -- induction chemotherapy -- perfusion parameters; Ultrasonics in medicine -- Periodicals; 616.07543
• DOI: 10.1002/jcu.23361
• Languages: English
• ISSNs: 0091-2751

Abstract

Abstract: In view of the inherent limitations associated with performing dynamic contrast enhanced‐magnetic resonance imaging (DCE‐MRI) in clinical settings, current study was designed to provide a proof of principle that Doppler sonography and DCE‐MRI derived perfusion parameters yield similar hemodynamic information from metastatic lymph nodes in squamous cell carcinomas of head and neck (HNSCCs). Strong positive correlations between volume fraction of plasma space in tissues ( V p ) and blood volume ( r = 0.72, p = 0.02) and between V p and %area perfused ( r = 0.65, p = 0.04) were observed. Additionally, a moderate positive correlation trending towards significance was obtained between volume transfer constant ( K trans ) and %area perfused ( r = 0.49, p = 0.09). Abstract : Doppler sonography provided similar information to those obtained by DCE‐MRI in characterizing tumor vasculature in head and neck cancers. Doppler sonography may be considered as an alternative imaging modality for assessing tumor perfusion, especially, for larger superficial metastatic nodes.