Bioheterojunction‐Engineered Polyetheretherketone Implants With Diabetic Infectious Micromilieu Twin‐Engine Powered Disinfection for Boosted Osteogenicity. Issue 45 (9th September 2022)

• Record Type: Journal Article
• Authors: Li, Bin; Shu, Rui; Dai, Wenyu; Yang, Fan; Xu, Hui; Shi, Xiuyuan; Li, Yunfei; Bai, Ding; Yang, Weizhong; Deng, Yi
• Is Part Of: Small. Volume 18:Issue 45(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-09-09
• Subjects: bioheterojunctions -- diabetic infectious micromilieu -- implants -- osseointegration -- polyetheretherketone; Nanotechnology -- Periodicals; Nanoparticles -- Periodicals; Microtechnology -- Periodicals; 620.5
• DOI: 10.1002/smll.202203619
• Languages: English
• ISSNs: 1613-6810

Abstract

Abstract: Diabetic infectious micromilieu (DIM) leads to a critical failure rate of osseointegration by virtue of two main peculiarities: high levels of topical glucose and inevitable infection. To tackle the daunting issue, a bioheterojunction‐engineered orthopedic polyetheretherketone (PEEK) implant consisting of copper sulfide/graphene oxide (CuS/GO) bioheterojunctions (bioHJs) and glucose oxidase (GO x ) is conceived and developed for DIM enhanced disinfection and boosted osseointegration. Under hyperglycemic micromilieu, GO x can convert surrounding glucose into hydrogen peroxide (H2 O2 ). Then, upon infectious micromilieu, the bioHJs enable the catalyzation of H2 O2 to highly germicidal hydroxyl radical (·OH). As a result, the engineered implants massacre pathogenic bacteria through DIM twin‐engine powered photo‐chemodynamic therapy in vitro and in vivo. In addition, the engineered implants considerably facilitate cell viability and osteogenic activity of osteoblasts under a hyperglycemic microenvironment via synergistic induction of copper ions (Cu 2+ ) and GO. In vivo studies using bone defect models of diabetic rats at 4 and 8 weeks further authenticate that bioHJ‐engineering PEEK implants substantially elevate their osseointegration through biofilm elimination and vascularization, as well as macrophage reprogramming. Altogether, the present study puts forward a tactic that arms orthopedic implants with DIM twin‐engine powered antibacterial and formidable osteogenic capacities for diabetic stalled osseointegration. Abstract : A diabetic infectious micromilieu‐targeted twin‐engine powered photo‐chemodynamic disinfection strategy is developed for polyetheretherketone implants armed with CuS/GO bioheterojunctions and GOx, in which GOx can convert surrounding glucose into H2 O2 while Cu 2+ ions enable catalyzation of H2 O2 to hydroxyl radicals in an infectious environment. In addition, the engineering implants substantially promote osseointegration activation under NIR irradiation, which provides a design paradigm for boosted diabetic osteogenicity.