Gamma Knife® stereotactic radiosurgery for intracranial cavernous malformations. (December 2022)

• Record Type: Journal Article
• Authors: Shanker, Mihir D.; Webber, Rebecca; Pinkham, Mark B.; Huo, Michael; Olson, Sarah; Hall, Bruce; Jayalath, Rumal; Watkins, Trevor; Foote, Matthew C.
• Is Part Of: Journal of clinical neuroscience. Volume 106(2022)
• Page Start: 96
• Page End: 102
• Publication Date: 2022-12
• Subjects: Stereotactic radiosurgery -- Cavernoma -- Cavernous malformation -- Gamma Knife; Brain -- Surgery -- Periodicals; Neurosciences -- Periodicals; Nervous system -- Surgery -- Periodicals; Brain -- surgery -- Periodicals; Neurosurgical Procedures -- Periodicals; Neurosciences -- Periodicals; Electronic journals; 616.8
• DOI: 10.1016/j.jocn.2022.10.015
• Languages: English
• ISSNs: 0967-5868

Abstract

Highlights: First reported Australian cohort of patients treated with Gamma Knife stereotactic radiosurgery (GKSRS) for cerebral cavernous malformations (CCMs). Largest pooled analysis of non-randomised studies to date assessing the impact of GKSRS on re-haemorrhage risk in CCMs. Eightfold reduction in haemorrhage events following GKSRS with majority of risk reduction occurring in the initial 2 years following treatment. Significant reduction in matched annual bleed rate from pre-GKSRS (52.1 %) compared to after SRS (12.3 %) (p < 0.001) [OR = 0.07, 95 % 0.008–0.283]. Treatment is safe overall with an overall low risk of morbidity (3% in the Australian cohort). Abstract: Introduction: Gamma Knife® stereotactic radiosurgery (GKSRS) is a non-invasive alternative to surgical resection for cerebral cavernous malformations (CCMs), especially in eloquent locations. Methodology: A retrospective review was performed on an Australian cohort of patients receiving GKSRS for CCMs at a single institution. All patients exhibited symptoms and/or radiological evidence of haemorrhage before therapy. The minimum follow-up was 1-year post-GKSRS. McNemar's test was used for differences in matched-pair outcomes pre- and post-GKSRS with an α = 0.05. A systematic review and meta-analysis was additionally performed to synthesise the current published evidence on the clinical efficacy of stereotactic radiosurgery in reducing haemorrhage risk in CCMs using a DerSimonian and Laird random effects model. Results: Thirty-five patients (39 cavernomas) underwent GKSRS. 87.2 % of patients had evidence of at least one haemorrhage before GKSRS and the remainder exhibited seizures. The median dose was 12.5 Gy in a single fraction (IQR 12–13). The median follow-up duration from GKSRS was 809 days (IQR 536–960). There was a significant reduction in matched annual bleed rate from pre-GKSRS (52.1 %) compared to after SRS (12.3 %) (p < 0.001) [OR = 0.07, 95 % 0.008–0.283] There was no statistically significant difference in seizure incidence pre- (30.7 %) versus post-GKSRS (17.9 %) (p = 0.13) [OR = 0.167, 95 %CI 0.004–1.37]. One patient (3 %) with a brainstem lesion experienced long-term treatment-related oedema with persistent ipsilateral weakness and tremors. On meta-analysis of 25 pooled studies, radiosurgery for the treatment of CCMs was associated with a statistically significantly relative risk (RR) reduction in haemorrhage events [random effects RR 0.12 (95 % CI 0.074–0.198), p < 0.001)], with most of the proportionate risk reduction occurring in the initial 2 years following SRS. Conclusion: GKSRS significantly reduces the annual rate of haemorrhage for intracranial cavernomas in this cohort and on meta-analysis, particularly in the first 2 years following treatment. The overall risk of treatment-related morbidity is low.