Mangasese doped polypyrole nanoparticels for photothermal/chemodynamic therapy and immune activation. (29th January 2023)

• Record Type: Journal Article
• Authors: Li, Zhuoxin; Zhou, Lingyi; Qin, Yuyan; Sun, Xin; Li, Qianzhe; Yang, Mengyu; Yu, Beibei; Du, Fengyi; Zhang, Miaomiao
• Is Part Of: Nanotechnology. Volume 34:Number 5(2023)
• Publication Date: 2023-01-29
• Subjects: polypyrrole nanoparticles -- photothermal therapy -- dendritic cells -- alkyl radical -- manganese ions; Nanotechnology -- Periodicals; Nanotechnology -- Periodicals; Nanotechnology; Publications périodiques; Nanotechnologies; Periodicals; 620.5
• DOI: 10.1088/1361-6528/ac9739
• Languages: English
• ISSNs: 0957-4484

Abstract

Abstract: Photothermal therapy (PTT) is a promising treatment that efficiently suppresses local cancer, but fails to induce a robust antitumor immune response against tumor metastasis and recurrence. In this study, a NIR responsive nano-immunostimulant (Mn/A-HP NI) is fabricated by entrapping manganese and azo-initiator (AIPH) into hyaluronic acid-based polypyrrole nanoparticle. The as-prepared Mn/A-HP NIs with a high photothermal conversion efficiencey of 20.17% dramatically induced the imunogenic cell death of tumor cells and triggered the release ATP and HMGB1. Meanwhile, the hyperthermia induced AIPH decomposition to produce alkyl radicals which further destroyed cancer cells. Furthermore, the Mn/A-HP NIs were capable of promoting the maturation and antigen cross-presentation ability of dendritic cells. Consequently, the multifunctional Mn/A-HP NIs provided a combined treatment via integrating PTT/chemo-dynamic therapy and immune activation for tumor therapy.