Effect and Mechanism of Exogenous Melatonin on Cognitive Deficits in Animal Models of Alzheimer's Disease: A Systematic Review and Meta-analysis. (21st November 2022)

• Record Type: Journal Article
• Authors: Zhai, Zhenwei; Xie, Danni; Qin, Tao; Zhong, Yanmei; Xu, Ying; Sun, Tao
• Is Part Of: Neuroscience. Volume 505(2022)
• Page Start: 91
• Page End: 110
• Publication Date: 2022-11-21
• Subjects: AD Alzheimer's disease -- MCI mild cognitive impairment -- CSF cerebrospinal fluid -- CNKI Chinese National Knowledge Infrastructure -- CBM China Biology Medicine disc -- VIP China Science and Technology Journal Database -- MWM Morris water maze -- NaN3 Chronic sodium azide -- APP amyloid precursor protein -- SD Sprague Dawley rat -- MD mean differences -- SMD standardized mean difference -- ICV intracerebroventricular -- SYRCLE Systematic Review Centre for Laboratory Animal Experimentation -- SP senile plaques -- NFT neurofibrillary tangles -- GSK3β Glycogen synthesis kinase 3β -- ADAM10 metalloproteinase domain-containing protein 10 -- CTF C-terminal fragment -- TNF-α tumour necrosis factor α -- IFN-γ interferon γ -- MT melatonin -- qd quaque die -- EGT ergothioneine -- DG D-galactose -- OXYS male senescence-accelerated OXYS rats -- PS1 presenilin 1 -- KM mice Kunming mice -- Tg transgenic mice or rats -- p.o. oral administration -- s.c. subcutaneous injection -- i.p. intraperitoneal injection -- Aβ amyloid-β -- ICR Institute of Cancer Research -- ELISA enzyme-linked immunosorbent assay -- SIRT1 Silent mating type information regulation 2 homolog 1; Alzheimer's Disease -- Melatonin -- Amyloid-β -- Animal Model -- Morris Water Maze -- Meta-analysis; Neurochemistry -- Periodicals; Neurophysiology -- Periodicals; Neurology -- Periodicals; Neurochimie -- Périodiques; Neurophysiologie -- Périodiques; Neurochemistry; Neurophysiology; Electronic journals; Periodicals; Electronic journals; 612.8
• DOI: 10.1016/j.neuroscience.2022.09.012
• Languages: English
• ISSNs: 0306-4522

Abstract

Highlights: A meta-analysis of melatonin (MT) for interventions of Alzheimer's disease (AD) animal models was conducted. MT markedly ameliorated learning ability of senescence-related model and metabolic-induced model. MT corrected memory deficit in the toxin-induced model. MT reduced amyloid-β levels in AD animal models. Abstract: Melatonin (MT) has been reported to control and prevent Alzheimer's disease (AD) in the clinic; however, the effect and mechanism of MT on AD have not been specifically described. Therefore, the main purpose of this meta-analysis was to explore the effect and mechanism of MT on AD models by studying behavioural indicators and pathological features. Seven databases were searched and 583 articles were retrieved. Finally, nine studies (13 analyses, 294 animals) were included according to pre-set criteria. Three authors independently judged the selected literature and the methodological quality. Meta-analysis showed that MT markedly ameliorated the learning ability by reducing the escape latency, and the memory deficit was significantly corrected by increasing the dwell time in the target quadrant and crossings over the platform location in the Morris Water Maze (MWM). Among the pathological features, subgroup analysis found that MT may ease the symptoms of AD mainly by reducing the deposition of Aβ40 and Aβ42 in the cortex. In addition, MT exerted a superior effect on ameliorating the learning ability of senescence-related and metabolic AD models, and corrected the memory deficit of the toxin-induced AD model. The study was registered at PROSPERO (CRD42021226594).