Sculpting Bio‐Inspired Surface Textures: An Adhesive Janus Periosteum. (1st July 2021)

• Record Type: Journal Article
• Authors: Yang, Yuhe; Xu, Tianpeng; Bei, Ho Pan; Zhao, Yuanjin; Zhao, Xin
• Is Part Of: Advanced functional materials. Volume 31:Number 37(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-07-01
• Subjects: anatomical pattern -- bio‐inspired surface textures -- bone regeneration -- Janus periosteum -- tissue adhesion; Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adfm.202104636
• Languages: English
• ISSNs: 1616-301X

Abstract

Abstract: Existing artificial periostea faces difficulty in supporting the entire bone repair cycle due to the absence of adhesion‐centric design and effective cell manipulation, leading to poor inhibition of soft tissue infiltration and induction of osteogenesis and angiogenesis. Here, a Janus periosteum with interior surface adhesion and exterior anatomical patterns to mimic the structure and function of natural periosteum is presented. Photo‐crosslinkable polymers are employed to replicate the exterior anisotropic surface structured microgrooves for cell fate manipulation and assemble gecko‐inspired fibrillar setae arrays for interior surface adhesion. To further bolster its underwater adhesiveness, mussel‐inspired poly (dopamine methacrylamide‐co‐hydroxyethyl methacrylate) (PDMH) is coated onto the periosteum surfaces. This periosteum presents adhesiveness with strong shear and normal adhesion in both dry and wet conditions due to the coordinated interactions of micro setae arrays and PDMH coating; it also boasts effective cell modulation for enhanced synchronous osteogenesis and angiogenesis, without the aid of growth factors. Moreover, the Janus periosteum is found to enhance bone regeneration in vivo with increased new bone formation and neovascularization. It is envisioned that this Janus periosteum will be able to streamline bone fracture surgical repair as a rapidly adhesive, low‐maintenance yet robust bandage to significantly cut down the healing phase. Abstract : A bio‐inspired Janus periosteum with anisotropic surface adhesion and anatomical pattern for bone regeneration is developed. It is integrated with the fibrillar setae arrays of gecko feet, adhesive protein of mussel byssus, and anatomical topographic microgrooved patterns of the natural periosteum. This anisotropic periosteum with tissue adhesion, new bone, and neovascular regeneration demonstrates great potential for clinical bone regeneration.