Placental pathology as a marker of brain injury in infants with hypoxic ischemic encephalopathy. (November 2022)

• Record Type: Journal Article
• Authors: Espinoza, Maria Liza; Brundler, Marie-Anne; Hasan, Shabih U.; Mohammad, Khorshid; Momin, Sarfaraz; Al Shaikh, Belal; Yusuf, Kamran
• Is Part Of: Early human development. Volume 174(2022)
• Publication Date: 2022-11
• Subjects: aEEG Amplitude electroencephalogram -- FIR Fetal Inflammatory Reaction -- HIE Hypoxic Ischaemic Encephalopathy -- IL Interleukin -- LGA Large for gestational age -- MIR Maternal Inflammatory Reaction -- PBW Placental birthweight -- PPV Positive-pressure ventilation -- SGA Small gestational age -- TNF Tumor necrosis factor; Neonate -- Hypoxemic ischemic encephalopathy -- Placental pathology; Fetus -- Periodicals; Neonatology -- Periodicals; Prenatal influences -- Periodicals; 612.65
• DOI: 10.1016/j.earlhumdev.2022.105683
• Languages: English
• ISSNs: 0378-3782

Abstract

Abstract: Background: Hypoxic Ischemic Encephalopathy (HIE) can lead to devastating consequences for the affected infant. Although therapeutic cooling benefits infants with moderate and severe HIE, differentiating mild from moderate-severe HIE may be challenging. The placenta reflects the fetal intrauterine environment and may reveal underlying processes that affect brain injury. Aim: To describe placental histopathology using the Amsterdam Placental Workshop Group Criteria in different grades of HIE. Study design: Retrospective cohort. Subjects: Infants admitted to a tertiary care neonatal intensive care unit with a diagnosis of HIE between 2011 and 2016. Outcome measure: Maternal and neonatal clinical variables and placental histopathology using the Amsterdam Placental Workshop Group Criteria were compared between mild and moderate-severe HIE. Mann-Whitney or t- test or ꭓ 2 were performed for bivariate associations as appropriate. To explain the relationship between placental pathology and severity of HIE odds ratios (ORs) and 95 % confidence intervals (CIs) were calculated using logistic regression models. Results: Of the 73 infants in the study, 23 had mild and 50 moderate-sever HIE. There was no difference in maternal and neonatal characteristics except for sentinel events which were higher in the moderate- severe group. On placental histopathology, acute inflammation, including fetal inflammatory reaction (FIR) were significantly higher in the moderate-severe group. After adjusting for confounders, FIR remained significantly associated with moderate-severe HIE, ORs 6.29, 95 % CI 1.5–25. Conclusion: Our study demonstrates FIR in the placenta is associated with severity of HIE. Highlights: Hypoxemic ischaemic encephalopathy (HIE) can have devastating effects on newborns. Moderate-severe HIE, amenable to cooling, is difficult to differentiate from mild HIE. Amsterdam classification was used to describe placental histopathology in HIE. Placental fetal inflammatory reaction was associated with moderate-severe HIE. The placenta should be examined in all cases of HIE.