Magnetic Relaxation and Modification of Thiol Groups on Co‐Mg Ferrite Nanoparticles for Theranostics. Issue 10 (12th May 2022)

• Record Type: Journal Article
• Authors: Katayanagi, Hikaru; Sakai, Naoki; Hamada, Sota; Usui, Akihito; Aoki, Kota; Kodama, Keita; Nashimoto, Kentaro; Hosokai, Yoshiyuki; Ichiyanagi, Yuko
• Is Part Of: ChemNanoMat. Volume 8:Issue 10(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-05-12
• Subjects: ferrite -- magnetic nanoparticles -- magnetic resonance imaging -- relaxation -- theranostics; Nanochemistry -- Periodicals; Nanostructured materials -- Periodicals; Nanochemistry; Nanostructured materials; Periodicals; 541.2
• DOI: 10.1002/cnma.202200014
• Languages: English
• ISSNs: 2199-692X

Abstract

Abstract: Co1‐ x Mg x Fe2 O4 ( x =0.0, 0.2, 0.4, 0.6, 0.8, 1.0) nanoparticles embedded in amorphous SiO2 with particle sizes of approximately 4.5 nm were prepared using an original wet chemical method. We performed spin‐echo magnetic resonance imaging measurements for Co1‐ x Mg x Fe2 O4 nanoparticles using a 0.3‐T MRI system. The particles exhibited a significant T 2 shortening effect compared with that of agarose, depending on the composition. All particles exhibited effective relaxivity, R2, and a significant contrast was observed in the phantom image. Furthermore, thiol group was modified to enable particles to bind specifically to maleimide proteins. These particles are expected to be potential theranostic agents. Abstract : Co1‐ x Mg x Fe2 O4 ( x =0.0, 0.2, 0.4, 0.6, 0.8, 1.0) nanoparticles surrounded by amorphous SiO2 of several nanometers in size were prepared using an original wet chemical method. These particles exhibited superparamagnetic behavior, and a significant T 2 shortening effect was observed. The thiol group was successfully modified on the ceramic insulator of Co‐ferrite nanoparticles.