A new tigliane-type diterpenoid from Euphorbia tirucalli. Issue 20 (13th October 2022)

• Record Type: Journal Article
• Authors: Weng, Han-Zhuang; Tian, Yang; Zhang, Jun-Sheng; Huang, Jia-Luo; Tang, Gui-Hua; Yin, Sheng
• Is Part Of: Natural product research. Volume 36:Issue 20(2022)
• Page Start: 5380
• Page End: 5386
• Publication Date: 2022-10-13
• Subjects: Euphorbia tirucalli -- tigliane diterpenoid -- P-glycoprotein inhibitor; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2021.1938039
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: Five tigliane (1 −5 ) and one ingenane (6 ) diterpenoids were isolated from the ethanol extract of Euphorbia tirucalli . The structures of these compounds were identified based on analysis of their spectroscopic data. Among them, compound 12- O -(2 E, 4 E, 6 E, 8 E -tetradecatetraenoyl)-13- O -isobutyroyl-4 β -deoxyphorbol (1 ) was a new tigliane. The Rho123 effluxion assay showed that tiglianes with a trans -fused 5/7 ring system such as compounds 1, 2, and 4 had potent inhibitory activity against P-glycoprotein in HepG2/ADR cells. GRAPHICAL ABSTRACT: UF0001