Risk factors for liver‐related mortality of patients with hepatitis C virus after sustained virologic response to direct‐acting antiviral agents. Issue 10 (26th August 2022)

• Record Type: Journal Article
• Authors: Hattori, Nobuhiro; Ikeda, Hiroki; Watanabe, Tsunamasa; Satta, Yosuke; Ehira, Takuya; Suzuki, Tatsuya; Kiyokawa, Hirofumi; Nakahara, Kazunari; Takahashi, Hideaki; Matsunaga, Kotaro; Matsumoto, Nobuyuki; Yasuda, Hiroshi; Suzuki, Michihiro; Itoh, Fumio; Tateishi, Keisuke
• Is Part Of: JGH open. Volume 6:Issue 10(2022)
• Page Start: 685
• Page End: 691
• Publication Date: 2022-08-26
• Subjects: diabetes mellitus -- direct‐acting antiviral agents -- hepatitis C virus -- survival -- sustained virologic response
• DOI: 10.1002/jgh3.12805
• Languages: English
• ISSNs: 2397-9070

Abstract

Abstract: Background and Aim: The aim of this study was to identify the factors associated with liver‐related and non‐liver‐related mortality of patients with hepatitis C virus (HCV) after sustained virologic response (SVR) to direct‐acting antiviral agents (DAAs). Methods: We conducted a retrospective, single‐center cohort study of HCV patients cured by DAAs. Results: A total of 330 patients with SVR to DAAs were eligible. The median follow‐up period was 3.38 years (inter‐quartile range: 2.03–4.58). The cumulative liver‐related or non‐liver‐related mortality rates at 1, 3, and 5 years were 0.00 or 1.29%, 2.87 or 3.60%, and 5.10 or 9.46, respectively. Among the liver‐related deaths, 9 of the 10 were from liver cancer. Among the non‐liver‐related deaths, the most common cause was malignancy. Through multivariate analysis using the Cox proportional hazard model, diabetes mellitus (DM, hazard ratio 13.1, 95% confidence interval 2.81–61.3) and a history of hepatocellular carcinoma (HCC, 12.8, 2.76–59.2), independently predicted liver‐related death. No variables were associated with non‐liver‐related death. Conclusion: Our findings suggest that DM and a history of HCC are risk factors for liver‐related mortality of HCV patients cured by DAAs. These results indicate that early management of HCV and HCC surveillance of diabetic patients after SVR are important to increase the chance of survival. Further studies are needed to confirm the association of DM and HCC history with survival. Abstract : Very few studies have assessed the factors associated with liver‐related mortality in patients with sustained virologic response (SVR) following direct‐acting antiviral agents (DAA) treatment. The findings of our cohort study are that diabetes mellitus and a history of hepatocellular carcinoma (HCC) are risk factors for the liver‐related mortality of HCV patients cured by DAA. The results indicate that early management of HCV and HCC surveillance of diabetic patients after SVR are important to increase the chance of survival.