Physiologically based pharmacokinetic (PBPK) modeling of BDE-209 following oral exposure in Chinese population. (November 2022)

• Record Type: Journal Article
• Authors: Zhang, Zhichun; Hu, Man; Xuan, Dongliang; Wu, Linying; Zhang, Yanfei; He, Gengsheng; Zhou, Ying
• Is Part Of: Food and chemical toxicology. Volume 169(2022)
• Publication Date: 2022-11
• Subjects: BDE-209 -- Pharmacokinetic behavior -- Plasma protein binding -- Physiologically based pharmacokinetic model -- Risk assessment -- Chinese population; Toxicology -- Periodicals; Food poisoning -- Periodicals; Food Poisoning -- Periodicals; Toxicology -- Periodicals; Toxicologie -- Périodiques; Intoxications alimentaires -- Périodiques; Food poisoning; Toxicology; Periodicals; Electronic journals; 615.9
• DOI: 10.1016/j.fct.2022.113416
• Languages: English
• ISSNs: 0278-6915

Abstract

Abstract: The wide usage of decabromodiphenyl ether (BDE-209) as additive brominated flame retardant has caused its widespread occurrence in the environment and high exposure risk in humans. Estimating its internal exposure dose and reconstruction of external exposure dose using physiologically based pharmacokinetic (PBPK) modelling approach is a key step in the risk assessment of BDE-209. However, the PBPK model for BDE-209 is currently unavailable. This study has established two oral permeability-limited PBPK models of BDE-209 without enterohepatic recirculation (EHR) (model 1) and with EHR (model 2) for Chinese population. Using the in vitro experiments, the average binding of BDE-209 to human plasma protein (99.64% ± 2.97%) was obtained. Moreover, blood sample analysis and systematic literature review were performed to obtain internal and external exposure data of BDE-209 used for model calibration and validation. The predictions of both models were within 2-fold of the observed, and a longer half-life of serum BDE-209 was observed in model 2 than model 1. Based on the models, a human biomonitoring guidance value (HBM-GV) of 93.61 μg/g lw was derived for BDE-209, and there is no health risk found for Chinese population currently. This study provides new quantitative assessment tools for health risk assessment of BDE-209. Graphical abstract: Image 1