An improved radiosynthesis of [18F]FAraG, a PET radiotracer for imaging T‐cell activation. (5th September 2022)

• Record Type: Journal Article
• Authors: Holt, Daniel P.; Dannals, Robert F.
• Is Part Of: Journal of labelled compounds & radiopharmaceuticals. Volume 65:Number 12(2022)
• Page Start: 302
• Page End: 308
• Publication Date: 2022-09-05
• Subjects: cGMP -- F‐18 -- FAraG -- PET chemistry -- radiosynthesis; Tracers (Chemistry) -- Periodicals; Radiopharmaceuticals -- Periodicals; 615.8424
• DOI: 10.1002/jlcr.3999
• Languages: English
• ISSNs: 0362-4803

Abstract

Abstract : In this concise practitioner protocol, the radiochemical synthesis of 2′‐deoxy‐2′‐[ 18 F]fluoro‐9‐β‐d ‐arabinofuranosylguanine ([ 18 F]FAraG) suitable for human positron emission tomography (PET) studies is described and the results from validation productions are presented. The high specific activity (sometimes referred to as molar activity) radiotracer product is prepared as a sterile, apyrogenic solution that conforms to current Good Manufacturing Practice (cGMP) requirements established by the U.S. Food and Drug Administration.