Deciphering the signaling mechanisms of β‐arrestin1 and β‐arrestin2 in regulation of cancer cell cycle and metastasis. Issue 10 (31st July 2022)

• Record Type: Journal Article
• Authors: Aamna, Bari; Kumar Dan, Aritra; Sahu, Raghaba; Behera, Santosh Kumar; Parida, Sagarika
• Is Part Of: Journal of cellular physiology. Volume 237:Issue 10(2022)
• Page Start: 3717
• Page End: 3733
• Publication Date: 2022-07-31
• Subjects: cancer cell proliferation -- cell cycle regulatory proteins -- GPCR signaling -- signal transduction -- β‐arrestins; Physiology -- Periodicals; Cell physiology -- Periodicals; 571.6
• DOI: 10.1002/jcp.30847
• Languages: English
• ISSNs: 0021-9541

Abstract

Abstract: β‐Arrestins are ubiquitously expressed intracellular proteins with many functions which interact directly and indirectly with a wide number of cellular partners and mediate downstream signaling. Originally, β‐arrestins were identified for their contribution to GPCR desensitization to agonist‐mediated activation, followed by receptor endocytosis and ubiquitylation. However, current investigations have now recognized that in addition to GPCR arresting (hence the name arrestin). β‐Arrestins are adaptor proteins that control the recruitment, activation, and scaffolding of numerous cytoplasmic signaling complexes and assist in G‐protein receptor signaling, thus bringing them into close proximity. They have participated in various cellular processes such as cell proliferation, migration, apoptosis, and transcription via canonical and noncanonical pathways. Despite their significant recognition in several physiological processes, these activities are also involved in the onset and progression of various cancers. This review delivers a concise overview of the role of β‐arrestins with a primary emphasis on the signaling processes which underlie the mechanism of β‐arrestins in the onset of cancer. Understanding these processes has important implications for understanding the therapeutic intervention and treatment of cancer in the future. Abstract : In this review, we present a summary of signaling pathways, regulated by β‐arrestin1 and β‐arrestin2, the impact of these pathways on cancer cell regulation, and their progression. An overview of the potential aspects of β‐arrestins (β‐arrestin1 and β‐arrestin2), which may be important therapeutic targets, and may regulate and control cancer metastasis are also discussed.