Cardiac Metastasis from Renal Cell Carcinoma Successfully Treated with Pazopanib: Impact of TKIs' Antiangiogenic Activity. Issue 6 (November 2014)

• Record Type: Journal Article
• Authors: Schinzari, Giovanni; Monterisi, Santa; Signorelli, Diego; Cona, Silvia; Cassano, Alessandra; Danza, Francesco; Barone, Carlo
• Is Part Of: Tumori. Volume 100:Issue 6(2014)
• Page Start: 298
• Page End: 300
• Publication Date: 2014-11
• Subjects: renal cell carcinoma -- cardiac metastasis -- tyrosine kinase inhibitors -- pazopanib; Cancer -- Periodicals; 616.994
• DOI: 10.1700/1778.19304
• Languages: English
• ISSNs: 0300-8916

Abstract

Cardiac metastasis from renal cell carcinoma, especially without neoplastic thrombosis of the vena cava, is extremely rare. The prognosis of patients with metastatic renal cell carcinoma has been radically influenced by the introduction of tyrosine kinase inhibitors, but very few reports in the literature have described their activity in heart metastasis. We report the case of a woman with a left ventricle metastasis from kidney cancer without renal vein involvement, who was treated with pazopanib. The patient achieved a prolonged partial response, with clear signs of metastasis devascularization and a favorable toxicity profile.