Treatable traits in the NOVELTY study. Issue 11 (21st July 2022)

• Record Type: Journal Article
• Authors: Agustí, Alvar; Rapsomaniki, Eleni; Beasley, Richard; Hughes, Rod; Müllerová, Hana; Papi, Alberto; Pavord, Ian D.; van den Berge, Maarten; Faner, Rosa
• Other Names: Benhabib Gabriel investigator.; Ruiz Xavier Bocca investigator.; del Olmo Ricardo investigator.; Lisanti Raul Eduardo investigator.; Marino Gustavo investigator.; Mattarucco Walter investigator.; Nogueira Juan investigator.; Parody Maria investigator.; Pascale Pablo investigator.; Rodriguez Pablo investigator.; Silva Damian investigator.; Svetliza Graciela investigator.; Victorio Carlos F. investigator.; Rolon Roxana Willigs investigator.; Yañez Anahi investigator.; Anderson Gary investigator.; Baines Stuart investigator.; Bowler Simon investigator.; Bremner Peter investigator.; Bull Sheetal investigator.; Carroll Patrick investigator.; Chaalan Mariam investigator.; Farah Claude investigator.; Hammerschlag Gary investigator.; Hancock Kerry investigator.; Harrington Zinta investigator.; Katsoulotos Gregory investigator.; Kim Joshua investigator.; Langton David investigator.; Lee Donald investigator.; Peters Matthew investigator.; Prassad Lakshman investigator.; Reddel Helen investigator.; Sajkov Dimitar investigator.; Santiago Francis investigator.; Simpson Frederick Graham investigator.; Tai Sze investigator.; Thomas Paul investigator.; Wark Peter investigator.; Cançado José Eduardo Delfini investigator.; Cunha Thúlio investigator.; Lima Marina investigator.; Pinto Cardoso Alexandre investigator.; Rabahi Marcelo investigator.; Anees Syed investigator.; Bertley John investigator.; Bell Alan investigator.; Cheema Amarjit investigator.; Chouinard Guy investigator.; Csanadi Michael investigator.; Dhar Anil investigator.; Dhillon Ripple investigator.; FitzGerald J. Mark investigator.; Kanawaty David investigator.; Kelly Allan investigator.; Killorn William investigator.; Landry Daniel investigator.; Luton Robert investigator.; Mandhane Piushkumar investigator.; McIvor Andrew investigator.; Pek Bonavuth investigator.; Petrella Robert investigator.; Sadatsafavi Mohsen investigator.; Stollery Daniel investigator.; Chen Meihua investigator.; Chen Yan investigator.; Gu Wei investigator.; Hui Kim Ming Christopher investigator.; Li Manxiang investigator.; Li Shiyue investigator.; Lijun Ma investigator.; Qin Guangyue investigator.; Song Weidong investigator.; Tan Wei investigator.; Tang Yijun investigator.; Wang Chen investigator.; Wang Tan investigator.; Wen Fuqiang investigator.; Wu Feng investigator.; Xiang Ping Chao investigator.; Xiao Zuke investigator.; Xiong Shengdao investigator.; Yang Jinghua investigator.; Yang Jingping investigator.; Zhang Caiqing investigator.; Zhang Min investigator.; Zhang Ping investigator.; Zhang Wei investigator.; Zheng Xiaohe investigator.; Zhu Dan investigator.; Grimaldos Fabio Bolivar investigator.; Arboleda Alejandra Cañas investigator.; Bueno Carlos Matiz investigator.; de Salazar Dora Molina investigator.; Bendstrup Elisabeth investigator.; Hilberg Ole investigator.; Kjellerup Carsten investigator.; Weinreich Ulla investigator.; Bonniaud Philippe investigator.; Brun Olivier investigator.; Burgel Pierre‐Régis investigator.; Chouaid Christos investigator.; Couturaud Francis investigator.; de Blic Jacques investigator.; Debieuvre Didier investigator.; Delsart Dominique investigator.; Demaegdt Axelle investigator.; Demoly Pascal investigator.; Deschildre Antoine investigator.; Devouassoux Gilles investigator.; Egron Carole investigator.; Falchero Lionel investigator.; Goupil François investigator.; Kessler Romain investigator.; Le Roux Pascal investigator.; Mabire Pascal investigator.; Mahay Guillaume investigator.; Martinez Stéphanie investigator.; Melloni Boris investigator.; Moreau Laurent investigator.; Raherison Chantal investigator.; Riviere Emilie investigator.; Roux‐Claudé Pauline investigator.; Soulier Michel investigator.; Vignal Guillaume investigator.; Yaici Azzedine investigator.; Aries Sven Philip investigator.; Bals Robert investigator.; Beck Ekkehard investigator.; Deimling Andreas investigator.; Feimer Jan investigator.; Grimm‐Sachs Vera investigator.; Groth Gesine investigator.; Herth Felix investigator.; Hoheisel Gerhard investigator.; Kanniess Frank investigator.; Lienert Thomas investigator.; Mronga Silke investigator.; Reinhardt Jörg investigator.; Schlenska Christian investigator.; Stolpe Christoph investigator.; Teber Ishak investigator.; Timmermann Hartmut investigator.; Ulrich Thomas investigator.; Velling Peter investigator.; Wehgartner‐Winkler Sabina investigator.; Welling Juergen investigator.; Winkelmann Ernst‐Joachim investigator.; Barbetta Carlo investigator.; Braido Fulvio investigator.; Cardaci Vittorio investigator.; Clini Enrico Maria investigator.; Costantino Maria Teresa investigator.; Cuttitta Giuseppina investigator.; di Gioacchino Mario investigator.; Fois Alessandro investigator.; Foschino‐Barbaro Maria Pia investigator.; Gammeri Enrico investigator.; Inchingolo Riccardo investigator.; Lavorini Federico investigator.; Molino Antonio investigator.; Nucera Eleonora investigator.; Papi Alberto investigator.; Patella Vincenzo investigator.; Pesci Alberto investigator.; Ricciardolo Fabio investigator.; Rogliani Paola investigator.; Sarzani Riccardo investigator.; Vancheri Carlo investigator.; Vincenti Rigoletta investigator.; Endo Takeo investigator.; Fujita Masaki investigator.; Hara Yu investigator.; Horiguchi Takahiko investigator.; Hosoi Keita investigator.; Ide Yumiko investigator.; Inomata Minehiko investigator.; Inoue Hiromasa investigator.; Inoue Koji investigator.; Inoue Sumito investigator.; Kato Motokazu investigator.; Kawasaki Masayuki investigator.; Kawayama Tomotaka investigator.; Kita Toshiyuki investigator.; Kobayashi Kanako investigator.; Koto Hiroshi investigator.; Nishi Koichi investigator.; Saito Junpei investigator.; Shimizu Yasuo investigator.; Shirai Toshihiro investigator.; Sugihara Naruhiko investigator.; Takahashi Ken‐ichi investigator.; Tashimo Hiroyuki investigator.; Tomii Keisuke investigator.; Yamada Takashi investigator.; Yanai Masaru investigator.; Javier Ruth Cerino investigator.; Peregrina Alfredo Domínguez investigator.; Corzo Marco Fernández investigator.; Gonzalez Efraín Montano investigator.; Ramírez‐Venegas Alejandra investigator.; Rendon Adrian investigator.; Boersma Willem investigator.; Djamin R. S. investigator.; Eijsvogel Michiel investigator.; Franssen Frits investigator.; Goosens Martijn investigator.; Graat‐Verboom Lidwien investigator.; Veen Johannes investigator.; Janssen Rob investigator.; Kuppens Kim investigator.; van den Berge Maarten investigator.; van de Ven Mario investigator.; Beasley Richard investigator.; Brunstad Ole Petter investigator.; Einvik Gunnar investigator.; Høines Kristian Jong investigator.; Khusrawi Alamdar investigator.; Oien Torbjorn investigator.; Chang Yoon‐Seok investigator.; Cho Young Joo investigator.; Hwang Yong Il investigator.; Kim Woo Jin investigator.; Koh Young‐Il investigator.; Lee Byung‐Jae investigator.; Lee Kwan‐Ho investigator.; Lee Sang‐Pyo investigator.; Lee Yong Chul investigator.; Lim Seong Yong investigator.; Min Kyung Hun investigator.; Oh Yeon‐Mok investigator.; Park Choon‐Sik investigator.; Park Hae‐Sim investigator.; Park Heung‐Woo investigator.; Rhee Chin Kook investigator.; Yoon Ho Joo investigator.; Yoon Hyoung‐Kyu investigator.; García‐Navarro Alvar Agusti investigator.; Andújar Rubén investigator.; Anoro Laura investigator.; García María Buendía investigator.; Mozo Paloma Campo investigator.; Campos Sergio investigator.; Maldonado Francisco Casas investigator.; Martínez Manuel Castilla investigator.; Serrano Carolina Cisneros investigator.; Casanova Lorena Comeche investigator.; Corbacho Dolores investigator.; Matías Felix Del Campo investigator.; Echave‐Sustaeta Jose investigator.; Corral Gloria Francisco investigator.; Setién Pedro Gamboa investigator.; Clemente Marta García investigator.; Núñez Ignacio García investigator.; Robaina Jose García investigator.; Salmones Mercedes García investigator.; Trigo Jose Maria Marín investigator.; Fernandez Marta Nuñez investigator.; Palomo Sara Nuñez investigator.; Rivera José Olaguibel investigator.; de Llano Luis Pérez investigator.; Bastida Ana Pueyo investigator.; Rañó Ana investigator.; González‐Moro José Rodríguez investigator.; Reig Albert Roger investigator.; Garrido José Velasco investigator.; Curiac Dan investigator.; Janson Christer investigator.; Lif‐Tiberg Cornelia investigator.; Luts Anders investigator.; Råhlen Lennart investigator.; Rustscheff Stefan investigator.; Adams Frances investigator.; Bradman Drew investigator.; Broughton Emma investigator.; Cosgrove John investigator.; Flood‐Page Patrick investigator.; Fuller Liz investigator.; Harrison Timothy investigator.; Hartley David investigator.; Hattotuwa Keith investigator.; Jones Gareth investigator.; Lewis Keir investigator.; McGarvey Lorcan investigator.; Morice Alyn investigator.; Pandya Preeti investigator.; Patel Manish investigator.; Price David investigator.; Roy Kay investigator.; Sathyamurthy Ramamurthy investigator.; Thiagarajan Swaminathan investigator.; Turner Alice investigator.; Vestbo Jørgen investigator.; Wedzicha Wisia investigator.; Wilkinson Tom investigator.; Wilson Pete investigator.; Al‐Asadi Lo'Ay investigator.; Anholm James investigator.; Averill Frank investigator.; Bansal Sandeep investigator.; Baptist Alan investigator.; Campbell Colin investigator.; Campos Michael A. investigator.; Chipps Bradley investigator.; Crook Gretchen investigator.; DeLeon Samuel investigator.; Eid Alain investigator.; Epstein Ellen investigator.; Fritz Stephen investigator.; Harris Hoadley investigator.; Hewitt Mitzie investigator.; Holguin Fernando investigator.; Hudes Golda investigator.; Jackson Richard investigator.; Kaufman Alan investigator.; Kaufman David investigator.; Klapholz Ari investigator.; Krishna Harshavardhan investigator.; Lee Daria investigator.; Lin Robert investigator.; Make Barry investigator.; Maselli‐Caceres Diego investigator.; Mehta Vinay investigator.; Moy James N. investigator.; Nwokoro Ugo investigator.; Parikh Purvi investigator.; Parikh Sudhir investigator.; Perrino Frank investigator.; Ruhlmann James investigator.; Sassoon Catherine investigator.; Settipane Russell A. investigator.; Sousa Daniel investigator.; Sriram Peruvemba investigator.; Wachs Richard investigator.;
• Is Part Of: Respirology. Volume 27:Issue 11(2022)
• Page Start: 929
• Page End: 940
• Publication Date: 2022-07-21
• Subjects: airways -- allergy -- asthma -- bronchitis -- chronic obstructive pulmonary disease -- COPD -- emphysema -- smoking; Respiratory organs -- Diseases -- Periodicals; Respiratory organs -- Periodicals; 612.2
• DOI: 10.1111/resp.14325
• Languages: English
• ISSNs: 1323-7799

Abstract

Abstract: Background and objective: Asthma and chronic obstructive pulmonary disease (COPD) are two prevalent and complex diseases that require personalized management. Although a strategy based on treatable traits (TTs) has been proposed, the prevalence and relationship of TTs to the diagnostic label and disease severity established by the attending physician in a real‐world setting are unknown. We assessed how the presence/absence of specific TTs relate to the diagnosis and severity of 'asthma', 'COPD' or 'asthma + COPD'. Methods: The authors selected 30 frequently occurring TTs from the NOVELTY study cohort (NOVEL observational longiTudinal studY; NCT02760329), a large ( n = 11, 226), global study that systematically collects data in a real‐world setting, both in primary care clinics and specialized centres, for patients with 'asthma' ( n = 5932, 52.8%), 'COPD' ( n = 3898, 34.7%) or both ('asthma + COPD'; n = 1396, 12.4%). Results: The results indicate that (1) the prevalence of the 30 TTs evaluated varied widely, with a mean ± SD of 4.6 ± 2.6, 5.4 ± 2.6 and 6.4 ± 2.8 TTs/patient in those with 'asthma', 'COPD' and 'asthma + COPD', respectively ( p < 0.0001); (2) there were no large global geographical variations, but the prevalence of TTs was different in primary versus specialized clinics; (3) several TTs were specific to the diagnosis and severity of disease, but many were not; and (4) both the presence and absence of TTs formed a pattern that is recognized by clinicians to establish a diagnosis and grade its severity. Conclusion: These results provide the largest and most granular characterization of TTs in patients with airway diseases in a real‐world setting to date. Abstract : This study shows which treatable traits are present and/or absent in patients diagnosed with 'asthma', 'COPD' (chronic obstructive pulmonary disease) and 'asthma + COPD' in a global, observational study of more than 11, 000 patients (NOVELTY), and how their prevalence changes with disease severity. See related Editorial