Correlations between peripheral levels of inflammatory mediators and frontolimbic structures in bipolar disorder: an exploratory analysis. (14th October 2022)

• Record Type: Journal Article
• Authors: Mohite, Satyajit; Salem, Haitham; Cordeiro, Thiago; Tannous, Jonika; Mwangi, Benson; Selvaraj, Sudhakar; Soares, Jair C.; Sanches, Marsal; Teixeira, Antonio L.
• Is Part Of: CNS spectrums. Volume 27:Number 5(2022)
• Page Start: 639
• Page End: 644
• Publication Date: 2022-10-14
• Subjects: Bipolar disorder -- neuroinflammation -- neuroimaging -- gray matter -- prefrontal cortex -- accelerated aging; Neuropsychiatry -- Periodicals; Nervous system -- Diseases -- Periodicals; Neurology -- Periodicals; 616.8005
• DOI: 10.1017/S1092852921000596
• Languages: English
• ISSNs: 1092-8529

Abstract

Abstract: Background: Altered peripheral immune/inflammatory system and brain volumetric changes have been implicated in the pathophysiology of bipolar disorder (BD). This study aimed to evaluate how peripheral levels of cytokines are related to volumetric brain changes in euthymic patients with BD. Methods: Euthymic patients with BD (n = 21) and healthy controls (n = 22) were enrolled in this exploratory study. Blood samples were collected on the same day of clinical assessment and neuroimaging. Cytokines were measured through cytometric bead array method. Neuroimaging data were acquired using a sagittal three-dimensional magnetic resonance imaging T1-weighted fast field echo sequence and was processed using FreeSurfer. Results: Compared to controls, BD patients had significantly lower volumes in the cingulate, medial-orbitofrontal (MOF) and parahippocampal regions. We found a negative correlation between right MOF volume and interferon-gamma levels ( β = −0.431, P = .049) and a positive correlation between interleukin-10 levels and left posterior cingulate volume ( β = 0.457, P = .048). Conclusion: Our results support the involvement of inflammatory pathways in structural brain changes in BD.