Phytoprostane and phenolic compounds from Chromolaena palmaris. Issue 20 (13th October 2022)

• Record Type: Journal Article
• Authors: Souza, Mariana R. Passos de; Ramos, Anderson V. G.; Oliveira, Josiane A. Monteiro de; Cabral, Márcia R. P.; Sampiron, Eloísa G.; Scodro, Regiane B. de Lima; Foglio, Mary Ann; Ruiz, Ana Lucia T. G.; Carmo, Marta R. B. do; Sarragiotto, Maria H.; Baldoqui, Debora C.
• Is Part Of: Natural product research. Volume 36:Issue 20(2022)
• Page Start: 5376
• Page End: 5379
• Publication Date: 2022-10-13
• Subjects: Chromolaena palmaris -- Asteraceae -- phytoprostanes -- flavonoids -- antiproliferative activity -- antitubercular activity; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2021.1937155
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: The chemical investigation of Chromolaena palmaris (Sch.Bip . ex Baker) R.M. King & H. Rob. expands the phytochemical composition knowledge of Chromolaena genus, since this is the first chemical investigation of this species. Twenty-five compounds were identified, including a phytoprostane, 17 flavonoids, 6 phenolic acids, and a caffeoyl-glucoside derivative obtained by classical chromatography and UHPLC-HRMS/MS analysis. Moreover, anti- Mycobacterium tuberculosis and antiproliferative activities of C. palmaris were evaluated. Dichloromethane fraction showed cytotoxicity towards human cancer cell lines, presenting TGI values on glioma (U251) of 27.8 μg mL −1 . Furthermore, compounds 1 and 2 exhibited antimicrobial activity against Mycobacterium tuberculosis with MIC of 62.5 and 15.6 μg mL −1, respectively. GRAPHICAL ABSTRACT: UF0001