Polymerization power: effectors of actin polymerization as regulators of T lymphocyte migration through complex environments. (3rd August 2021)

• Record Type: Journal Article
• Authors: Thompson, Scott B.; Waldman, Monique M.; Jacobelli, Jordan
• Is Part Of: FEBS journal. Volume 289:Number 20(2022)
• Page Start: 6154
• Page End: 6171
• Publication Date: 2021-08-03
• Subjects: Arp2/3 -- cytoskeleton -- formin -- motility -- VASP; Biochemistry -- Periodicals; Molecular biology -- Periodicals; Pathology, Molecular -- Periodicals; 572
• DOI: 10.1111/febs.16130
• Languages: English
• ISSNs: 1742-464X

Abstract

Abstract : During their life span, T cells are tasked with patrolling the body for potential pathogens. To do so, T cells migrate through numerous distinct anatomical sites and tissue environments with different biophysical characteristics. To migrate through these different environments, T cells use various motility strategies that rely on actin network remodeling to generate shape changes and mechanical forces. In this review, we initially discuss the migratory journey of T cells and then cover the actin polymerization effectors at play in T cells, and finally, we focus on the function of these effectors of actin cytoskeleton remodeling in mediating T‐cell migration through diverse tissue environments. Specifically, we will discuss the current state of the field pertaining to our understanding of the roles in T‐cell migration played by members of the three main families of actin polymerization machinery: the Arp2/3 complex; formin proteins; and Ena/VASP proteins. Abstract : To perform their functions, T cell migrate through tissue environments with varying biophysical properties. Migration within these different tissues relies on actin network remodeling and the use of various motility strategies. In this review, we discuss the role of actin polymerizing proteins, including formins, Ena/VASP proteins, and the Arp2/3 complex, in enabling T‐cell migration modes through diverse tissue environments.