2022 American College of Rheumatology/EULAR classification criteria for Takayasu arteritis. Issue 12 (9th November 2022)

• Record Type: Journal Article
• Authors: Grayson, Peter C; Ponte, Cristina; Suppiah, Ravi; Robson, Joanna C; Gribbons, Katherine Bates; Judge, Andrew; Craven, Anthea; Khalid, Sara; Hutchings, Andrew; Danda, Debashish; Luqmani, Raashid A; Watts, Richard A; Merkel, Peter A
• Other Names: author non-byline.; Gatenby Paul author non-byline.; Hill Catherine author non-byline.; Ranganathan Dwarakanathan author non-byline.; Kronbichler Andreas author non-byline.; Blockmans Daniel author non-byline.; Barra Lillian author non-byline.; Carette Simon author non-byline.; Pagnoux Christian author non-byline.; Dhindsa Navjot author non-byline.; Fifi-Mah Aurore author non-byline.; Khalidi Nader author non-byline.; Liang Patrick author non-byline.; Milman Nataliya author non-byline.; Pineau Christian author non-byline.; Tian Xinping author non-byline.; Wang Guochun author non-byline.; Wang Tian author non-byline.; Zhao Ming-hui author non-byline.; Tesar Vladimir author non-byline.; Baslund Bo author non-byline.; Hammam Nevin author non-byline.; Shahin Amira author non-byline.; Pirila Laura author non-byline.; Putaala Jukka author non-byline.; Hellmich Bernhard author non-byline.; Henes Jörg author non-byline.; Holle Julia author non-byline.; Moosig Frank author non-byline.; Lamprecht Peter author non-byline.; Neumann Thomas author non-byline.; Schmidt Wolfgang author non-byline.; Sunderkoetter Cord author non-byline.; Szekanecz Zoltan author non-byline.; Danda Debashish author non-byline.; Das Siddharth author non-byline.; Gupta Rajiva author non-byline.; Rajasekhar Liza author non-byline.; Sharma Aman author non-byline.; Wagh Shrikant author non-byline.; Clarkson Michael author non-byline.; Molloy Eamonn author non-byline.; Salvarani Carlo author non-byline.; Schiavon Franco author non-byline.; Tombetti Enrico author non-byline.; Vaglio Augusto author non-byline.; Amano Koichi author non-byline.; Arimura Yoshihiro author non-byline.; Dobashi Hiroaki author non-byline.; Fujimoto Shouichi author non-byline.; Harigai Masayoshi author non-byline.; Hirano Fumio author non-byline.; Hirahashi Junichi author non-byline.; Honma Sakae author non-byline.; Kawakami Tamihiro author non-byline.; Kobayashi Shigeto author non-byline.; Kono Hajime author non-byline.; Makino Hirofumi author non-byline.; Matsui Kazuo author non-byline.; Muso Eri author non-byline.; Suzuki Kazuo author non-byline.; Ikeda Kei author non-byline.; Takeuchi Tsutomu author non-byline.; Tsukamoto Tatsuo author non-byline.; Uchida Shunya author non-byline.; Wada Takashi author non-byline.; Yamada Hidehiro author non-byline.; Yamagata Kunihiro author non-byline.; Yumura Wako author non-byline.; Lai Kan Sow author non-byline.; Flores-Suarez Luis Felipe author non-byline.; Hinojosa-Azaola Andrea author non-byline.; Rutgers Bram author non-byline.; Tak Paul-Peter author non-byline.; Grainger Rebecca author non-byline.; Quincey Vicki author non-byline.; Stamp Lisa author non-byline.; Suppiah Ravi author non-byline.; Besada Emilio author non-byline.; Diamantopoulos Andreas author non-byline.; Sznajd Jan author non-byline.; Azevedo Elsa author non-byline.; Geraldes Ruth author non-byline.; Rodrigues Miguel author non-byline.; Santos Ernestina author non-byline.; Song Yeong-Wook author non-byline.; Moiseev Sergey author non-byline.; Hocevar Alojzija author non-byline.; Cid Maria Cinta author non-byline.; Moreno Xavier Solanich author non-byline.; Atukorala Inoshi author non-byline.; Berglin Ewa author non-byline.; Mohammed Aladdin author non-byline.; Segelmark Mårten author non-byline.; Daikeler Thomas author non-byline.; Direskeneli Haner author non-byline.; Hatemi Gulen author non-byline.; Kamali Sevil author non-byline.; Karadag Ömer author non-byline.; Pehlevan Seval author non-byline.; Adler Matthew author non-byline.; Basu Neil author non-byline.; Bruce Iain author non-byline.; Chakravarty Kuntal author non-byline.; Dasgupta Bhaskar author non-byline.; Flossmann Oliver author non-byline.; Gendi Nagui author non-byline.; Hassan Alaa author non-byline.; Hoyles Rachel author non-byline.; Jayne David author non-byline.; Jones Colin author non-byline.; Klocke Rainer author non-byline.; Lanyon Peter author non-byline.; Laversuch Cathy author non-byline.; Luqmani Raashid author non-byline.; Robson Joanna author non-byline.; Magliano Malgorzata author non-byline.; Mason Justin author non-byline.; Maw Win Win author non-byline.; McInnes Iain author non-byline.; Mclaren John author non-byline.; Morgan Matthew author non-byline.; Morgan Ann author non-byline.; Mukhtyar Chetan author non-byline.; O'Riordan Edmond author non-byline.; Patel Sanjeev author non-byline.; Peall Adrian author non-byline.; Robson Joanna author non-byline.; Venkatachalam Srinivasan author non-byline.; Vermaak Erin author non-byline.; Menon Ajit author non-byline.; Watts Richard author non-byline.; Yee Chee-Seng author non-byline.; Albert Daniel author non-byline.; Calabrese Leonard author non-byline.; Chung Sharon author non-byline.; Forbess Lindsy author non-byline.; Gaffo Angelo author non-byline.; Gewurz-Singer Ora author non-byline.; Grayson Peter author non-byline.; Liang Kimberly author non-byline.; Matteson Eric author non-byline.; Merkel Peter A. author non-byline.; Rhee Rennie author non-byline.; Springer Jason author non-byline.; Sreih Antoine author non-byline.;
• Is Part Of: Annals of the rheumatic diseases. Volume 81:Issue 12(2022)
• Page Start: 1654
• Page End: 1660
• Publication Date: 2022-11-09
• Subjects: Autoimmune Diseases -- Behcet Syndrome -- Cardiovascular Diseases; Rheumatism -- Periodicals; 616.723005
• DOI: 10.1136/ard-2022-223482
• Languages: English
• ISSNs: 0003-4967

Abstract

Abstract : Objective: To develop and validate new classification criteria for Takayasu arteritis (TAK). Methods: Patients with vasculitis or comparator diseases were recruited into an international cohort. The study proceeded in six phases: (1) identification of candidate criteria items, (2) collection of candidate items present at diagnosis, (3) expert panel review of cases, (4) data‐driven reduction of candidate items, (5) derivation of a points‐based classification score in a development data set and (6) validation in an independent data set. Results: The development data set consisted of 316 cases of TAK and 323 comparators. The validation data set consisted of an additional 146 cases of TAK and 127 comparators. Age ≤60 years at diagnosis and imaging evidence of large‐vessel vasculitis were absolute requirements to classify a patient as having TAK. The final criteria items and weights were as follows: female sex (+1), angina (+2), limb claudication (+2), arterial bruit (+2), reduced upper extremity pulse (+2), reduced pulse or tenderness of a carotid artery (+2), blood pressure difference between arms of ≥20 mm Hg (+1), number of affected arterial territories (+1 to +3), paired artery involvement (+1) and abdominal aorta plus renal or mesenteric involvement (+3). A patient could be classified as having TAK with a cumulative score of ≥5 points. When these criteria were tested in the validation data set, the model area under the curve was 0.97 (95% CI 0.94 to 0.99) with a sensitivity of 93.8% (95% CI 88.6% to 97.1%) and specificity of 99.2% (95% CI 96.7% to 100.0%). Conclusion: The 2022 American College of Rheumatology/EULAR classification criteria for TAK are now validated for use in research.