Mechanisms of efferocytosis in determining inflammation resolution: Therapeutic potential and the association with cardiovascular disease. (20th September 2022)

• Record Type: Journal Article
• Authors: Zhang, Jishou; Ding, Wen; Zhao, Mengmeng; Liu, Jianfang; Xu, Yao; Wan, Jun; Wang, Menglong
• Is Part Of: British journal of pharmacology. Volume 179:Number 23(2022)
• Page Start: 5151
• Page End: 5171
• Publication Date: 2022-09-20
• Subjects: atherosclerosis -- efferocytosis -- ischaemia/reperfusion injury -- myocardial infarction -- resolution of inflammation; Pharmacology -- Periodicals; Chemotherapy -- Periodicals; Drug Therapy -- Periodicals; Pharmacology -- Periodicals; 615.1
• DOI: 10.1111/bph.15939
• Languages: English
• ISSNs: 0007-1188

Abstract

Abstract : Efferocytosis is defined as the clearance of apoptotic cells (ACs) in physiological and pathological states and is performed by efferocytes, such as macrophages. Efferocytosis can lead to the resolution of inflammation and restore tissue homoeostasis; however, the mechanisms of efferocytosis in determining inflammation resolution are still not completely understood, and the effects of efferocytosis on other proresolving properties need to be explored and explained. In this review, the process of efferocytosis will be summarized briefly, and then these mechanisms and effects will be thoroughly discussed. In addition, the association between mechanisms of efferocytosis in determining resolution of inflammation and cardiovascular diseases will also be reviewed, as an understanding of this association may provide information on novel treatment targets. Abstract : Efferocytosis exerts its proresolving effects by dampening proinflammatory signalling, producing proresolving mediators, modulating macrophage phenotype and promoting Treg cell response, which contributes to the treatment of atherosclerosis and myocardial injury.