Biomimetic Aggregation‐Induced Emission Nanodots with Hitchhiking Function for T Cell‐Mediated Cancer Targeting and NIR‐II Fluorescence‐Guided Mild‐Temperature Photothermal Therapy (Adv. Funct. Mater. 45/2022). (3rd November 2022)

• Record Type: Journal Article
• Authors: Yang, Xing; Yang, Ting; Liu, Qiqi; Zhang, Xiuwen; Yu, Xinghua; Kwok, Ryan T. K.; Hai, Luo; Zhang, Pengfei; Tang, Ben Zhong; Cai, Lintao; Gong, Ping
• Is Part Of: Advanced functional materials. Volume 32:Number 45(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-11-03
• Subjects: aggregation‐induced emissions -- biomimetic nanoparticles -- dendritic cells -- NIR‐II -- photothermal therapies; Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adfm.202270254
• Languages: English
• ISSNs: 1616-301X

Abstract

Abstract : Biomimetic AIE Nanodots In article number 2206346, Zhang, Cai, Gong, and co‐workers report biomimetic aggregation‐induced emission (AIE) nanodots based on dendritic cell membrane coating on nanoaggregate of NIR‐II AIEgens. These nanodots can hitchhike on endogenous T cells during blood circulation to enhance the tumor delivery efficiency and stimulate T cells in the immunosuppressive tumor microenvironment secreting cytokine TNF‐α and inhibiting the over‐expression of HSP70 during NIR‐II fluorescence‐guided photothermal therapy to induce tumor apoptosis under mild temperature.