The human host response to monkeypox infection: a proteomic case series study. Issue 11 (28th September 2022)

• Record Type: Journal Article
• Authors: Wang, Ziyue; Tober‐Lau, Pinkus; Farztdinov, Vadim; Lemke, Oliver; Schwecke, Torsten; Steinbrecher, Sarah; Muenzner, Julia; Kriedemann, Helene; Sander, Leif Erik; Hartl, Johannes; Mülleder, Michael; Ralser, Markus; Kurth, Florian
• Is Part Of: EMBO molecular medicine. Volume 14:Issue 11(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-09-28
• Subjects: host response -- monkeypox virus -- proteomics -- viral infection; Molecular biology -- Periodicals; Medical genetics -- Periodicals; Pathology, Molecular -- Periodicals; 616.04205
• DOI: 10.15252/emmm.202216643
• Languages: English
• ISSNs: 1757-4676

Abstract

Abstract: The rapid rise of monkeypox (MPX) cases outside previously endemic areas prompts for a better understanding of the disease. We studied the plasma proteome of a group of MPX patients with a similar infection history and clinical manifestation typical for the current outbreak. We report that MPX in this case series is associated with a strong plasma proteomic response among nutritional and acute phase response proteins. Moreover, we report a correlation between plasma proteins and disease severity. Contrasting the MPX host response with that of COVID‐19, we find a range of similarities, but also important differences. For instance, CFHR1 is induced in COVID‐19, but suppressed in MPX, reflecting the different roles of the complement system in the two infectious diseases. Of note, the spatial overlap in response proteins suggested that a COVID‐19 biomarker panel assay could be repurposed for MPX. Applying a targeted protein panel assay provided encouraging results and distinguished MPX cases from healthy controls. Hence, our results provide a first proteomic characterization of the MPX human host response and encourage further research on protein‐panel assays in emerging infectious diseases. Synopsis: Plasma proteome analysis of patients with monkeypox (MPX) reveals key features of the host response to MPX infection. A COVID‐19‐derived biomarker panel was repurposed for this different viral disease. Distinct changes, especially in proteins associated with the acute phase and nutritional response, distinguish MPX cases from healthy controls. Several proteins, including SERPINA3, SAA1, LRG1, and apolipoproteins, correlate well with disease severity measured by the number of skin lesions. Due to the overlap in host response proteins, the possibility of repurposing biomarker panels across different viral infections was explored to improve pandemic preparedness. Abstract : Plasma proteome analysis of patients with monkeypox (MPX) reveals key features of the host response to MPX infection. A COVID‐19‐derived biomarker panel was repurposed for this different viral disease.