Investigation of the CO releasing ability of azachalcone bound Mn(I) tricarbonyl complexes and their antiproliferative properties. (27th September 2022)

• Record Type: Journal Article
• Authors: Thomas, Jisha Mary; Kuduvalli, Shreyas S.; Anitha, Thirugnanasambandhar Sivasubramanian; Sivasankar, Chinnappan
• Is Part Of: Applied organometallic chemistry. Volume 36:Number 12(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-09-27
• Subjects: azachalcone -- carbon monoxide -- green light -- manganese -- photoCORM; Organometallic chemistry -- Periodicals; Organometallic compounds -- Periodicals; 547.05
• DOI: 10.1002/aoc.6896
• Languages: English
• ISSNs: 0268-2605

Abstract

Abstract : A series of [Mn(CO)3 (L)Br] complexes (1 –5 ) are synthesized using azachalcones as ligands, wherein they are coordinated to the manganese metal through the nitrogen and oxygen donor atoms. Their characterization using various spectroscopic techniques, stability analysis in dimethyl sulfoxide solvent, photodecomposition analysis, and antiproliferative effect are reported herein. These complexes release CO upon exposure to green light radiation. DFT and TD‐DFT investigations are also reported to gather information regarding the electronic features of these complexes. Abstract : The synthesis and characterization of five Mn(I) tricarbonyl complexes stabilized by azachalcone ligands are reported along with their CO releasing ability under green light irradiation. DFT and TD‐DFT analysis of these complexes revealed the orbitals involved in the transitions leading to the CO release. Finally, the cell viability assay of the complexes against U‐87 MG glioma cell is also discussed.