First Nerve‐Related Immunoprobe for Guidance of Renal Denervation through Colocalization of NIR‐II and Photoacoustic Bioimaging. Issue 21 (13th September 2022)

• Record Type: Journal Article
• Authors: Yibing, Shi; Minna, Tang; Sidi, Zhang; Chenchen, Hu; Cheng, Li; Quanxiao, Li; Keke, Huang; Wenping, Song; Zhixing, Li; Wenshu, Li; Zhenlin, Yang; Yanling, Wu; Fuyou, Li; Jialu, Hu; Tianlei, Ying
• Is Part Of: Advanced healthcare materials. Volume 11:Issue 21(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-09-13
• Subjects: anti‐tyrosine hydroxylase antibodies -- immunoprobes -- photoacoustic imaging -- renal sympathetic denervation -- second near‐infrared imaging; Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/adhm.202201212
• Languages: English
• ISSNs: 2192-2640

Abstract

Abstract: Nerve‐related fluorophores generally locate in the visible or near‐infrared region with shallow penetration depth and easy uptake by surrounding tissues. Prolonging the optical window promotes resolution by minimizing photoscattering and eliminating autofluorescence for NIR‐II (second near infrared; 1000–1700 nm) and photoacoustic bioimaging. In addition, combination of the two could help in colocalization of targets at the 3D level. Catheter‐based renal sympathetic denervation (RDN), an alternative treatment recently finishing its clinical evaluation for treating resistant hypertension, is highly dependent on experience and in urgent demand for in vivo guidance in locating the nerve over the renal artery. Here, an NIR‐II and photoacoustic bioimaging system based on a dye‐modified anti‐tyrosine‐hydroxylase antibody (TH‐ICGM) to illustrate the peritoneal sympathetic nerve‐related region are combined. With high resolution (0.15 mm) in NIR‐II region for both absorbance ( λ ex = 925 nm) and fluorescence (bioimaging in λ em ≥ 1300 nm), TH‐ICGM succeeds in providing 3D coordinates of procedure position with a precision in 0.1 mm. As the first nerve‐related NIR‐II immunoprobe, TH‐ICGM has great clinical potential as assistance for nerve‐related interventions. Abstract : Current nerve‐related probes obtain limited penetration depth and nonspecific uptake by surrounding tissues. Here, a near infrared‐II (NIR‐II) immunoprobe anti‐tyrosine‐hydroxylase‐based immunoprobe (TH‐ICGM) with versatile design properties, high imaging resolution and dual‐channel imaging capacity (NIR‐II and photoacoustic imaging) providing intraoperation guidance and postoperation evaluation for renal denervation is reported. As the first nerve‐related NIR‐II immunoprobe, TH‐ICGM has great clinical potential as assistance for nerve‐related interventions.