Cold atmospheric plasma does not affect the regenerative potential of the pulp in rats. Issue 11 (28th June 2022)

• Record Type: Journal Article
• Authors: Gund, Madline P.; Hannig, Matthias; Laschke, Matthias W.; Lehmann, Antje; Schindler, Axel; Rupf, Stefan
• Is Part Of: Plasma processes and polymers. Volume 19:Issue 11(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-06-28
• Subjects: cold atmospheric plasma -- composite filling -- mucosa -- pulp -- rat -- tooth cavity preparation; Plasma polymerization -- Periodicals; Plasma-enhanced chemical vapor deposition -- Periodicals; Plasma chemistry -- Periodicals
• DOI: 10.1002/ppap.202200093
• Languages: English
• ISSNs: 1612-8850

Abstract

Abstract: The aim of this study was to investigate the effect of cold atmospheric plasma (CAP) treatment combined with adhesive filling therapy on rat dental pulps. Cavities were prepared in the first maxillary molars of 20 Sprague Dawley rats. The first molar and the unprepared second molar of one randomly selected maxillary quadrant were treated with CAP. The prepared cavities were filled with composite. After 24 h and 28 days, 10 rats each were killed. Teeth were demineralized and embedded in paraffin and histological sections were stained with hematoxylin–eosin and chloracetatesterase. None of the pulps displayed necrosis. Plasma treatment caused no additional alteration to the dental pulp in combination with adhesive filling therapy. These findings indicate that plasma treatment is compatible with the regenerative potential of the pulp. Abstract : The aim of this study was to investigate the effect of cold atmospheric plasma treatment combined with adhesive filling therapy on rat dental pulps. Plasma treatment had no additional destructive effect on the pulp compared to controls. Mucosal damage (24 h) was also observed. Nevertheless, considering the great benefit, taking into account the high regenerative capacity (no changes after 28 days) of the oral mucosa, the use of plasma is reasonable.