Biohybrid Response Microparticles Decorated with Trained‐MSCs for Acute Liver Failure Recovery. Issue 21 (2nd September 2022)

• Record Type: Journal Article
• Authors: Wang, Jinglin; Huang, Danqing; Yu, Hang; Ren, Haozhen; Shang, Luoran
• Is Part Of: Advanced healthcare materials. Volume 11:Issue 21(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-09-02
• Subjects: acute liver failure -- inverse opal -- microcarriers -- structural color -- trained immunity; Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/adhm.202201085
• Languages: English
• ISSNs: 2192-2640

Abstract

Abstract: Microcarrier‐based mesenchymal stem cells (MSCs) delivery have attracted increasing attention in acute liver failure (ALF) therapy, while there is still room for improvement in terms of improving cell loading efficiency, enhancing anti‐inflammatory features, and controlling cell release. Here, novel lipopolysaccharide (LPS)‐composited magnetic‐thermal responsive inverse opal particles (MIOPs) are presented for the delivery of MSCs. The MIOPs are composed of a chitosan inverse opal skeleton filled with a hydrogel containing LPS, poly( N ‐isopropylacrylamide), and Fe3 O4 nanoparticles. Benefitting from the biocompatible chitosan component and the huge specific surface area, the resultant MIOPs can capture MSCs in a nondestructive way. Furthermore, LPS can be released from the MIOPs under the stimulation of an alternating magnetic field, by which the MSCs are activated to gain the feature of "trained immunity." Moreover, this process can be monitored in real‐time by the structural color change of the MIOPs. With that, the MSCs‐laden MIOPs are employed in rats with ALF, and they exhibit obvious anti‐inflammatory and therapeutic efficacy superior to untrained MSCs. These performances make the MIOPs a distinctive cell delivery platform for clinical tissue recovery applications. Abstract : A platform employing biohybrid magnetic responsive inverse opal microparticles for the training and delivery of mesenchymal stem cells (MSCs) is presented, and the whole process can be monitored visually. This platform promotes anti‐inflammatory response of MSCs that contributes to remarkable effect on the repair of damaged liver.