Intensive care unit resources and patient‐centred outcomes in severe COVID‐19: a prospective single‐centre economic evaluation. (29th August 2022)

• Record Type: Journal Article
• Authors: Schallner, N.; Lieberum, J.; Kalbhenn, J.; Bürkle, H.; Daumann, F.
• Is Part Of: Anaesthesia. Volume 77:Number 12(2022)
• Page Start: 1336
• Page End: 1345
• Publication Date: 2022-08-29
• Subjects: cost‐utility analysis -- COVID‐19 -- health‐related quality of life -- outcome assessment -- quality‐adjusted life years; Anesthesia -- Periodicals; 617.96
• DOI: 10.1111/anae.15844
• Languages: English
• ISSNs: 0003-2409

Abstract

Summary: During the COVID‐19 pandemic, ICU bed shortages sparked a discussion about resource allocation. We aimed to analyse the value of ICU treatment of COVID‐19 from a patient‐centred health economic perspective. We prospectively included 49 patients with severe COVID‐19 and calculated direct medical treatment costs. Quality of life was converted into aggregated quality‐adjusted life years using the statistical remaining life expectancy. Costs for non‐treatment as the comparator were estimated using the value of statistical life year approach. We used multivariable linear or logistic regression to identify predictors of treatment costs, quality of life and survival. Mean (SD) direct medical treatment costs were higher in patients in ICU with COVID‐19 compared with those without (£60, 866 (£42, 533) vs. £8282 (£14, 870), respectively; p < 0.001). This was not solely attributable to prolonged ICU length of stay, as costs per day were also higher (£3115 (£1374) vs. £1490 (£713), respectively; p < 0.001), independent of overall disease severity. We observed a beneficial cost‐utility value of £7511 per quality‐adjusted life‐year gained, even with a more pessimistic assumption towards the remaining life expectancy. Extracorporeal membrane oxygenation therapy provided no additional quality‐adjusted life‐year benefit. Compared with non‐treatment (costs per lost life year, £106, 085), ICU treatment (costs per quality‐adjusted life‐year, £7511) was economically preferable, even with a pessimistic interpretation of patient preferences for survival (sensitivity analysis of the value of statistical life year, £48, 848). Length of ICU stay was a positive and extracorporeal membrane oxygenation a negative predictor for quality of life, whereas costs per day were a positive predictor for mortality. These data suggest that despite high costs, ICU treatment for severe COVID‐19 may be cost‐effective for quality‐adjusted life‐years gained.