Ultrasound‐Enhanced Antibacterial Activity of Polymeric Nanoparticles for Eradicating Bacterial Biofilms. Issue 21 (9th September 2022)

• Record Type: Journal Article
• Authors: Gopalakrishnan, Sanjana; Gupta, Aarohi; Makabenta, Jessa M. V.; Park, Jungmi; Amante, John J.; Chattopadhyay, Aritra Nath; Matuwana, Dorcas; Kearney, Cathal J.; Rotello, Vincent M.
• Is Part Of: Advanced healthcare materials. Volume 11:Issue 21(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-09-09
• Subjects: biofilm disruption -- biofilm eradication -- MRSA biofilm treatment -- polymeric nanoparticles -- synergistic antimicrobial therapy -- ultrasound treatment; Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/adhm.202201060
• Languages: English
• ISSNs: 2192-2640

Abstract

Abstract: Bacterial biofilms are a major healthcare concern resulting in refractory conditions such as chronic wounds, implant infections and failure, and multidrug‐resistant infections. Aggressive and invasive strategies are employed to cure biofilm infections but are prone to long and expensive treatments, adverse side‐effects, and low patient compliance. Recent strategies such as ultrasound‐based therapies and antimicrobial nanomaterials have shown some promise in the effective eradication of biofilms. However, maximizing therapeutic effect while minimizing healthy tissue damage is a key challenge that needs to be addressed. Here a combination treatment involving ultrasound and antimicrobial polymeric nanoparticles (PNPs) that synergistically eradicate bacterial biofilms is reported. Ultrasound treatment rapidly disrupts biofilms and increases penetration of antimicrobial PNPs thereby enhancing their antimicrobial activity. This results in superior biofilm toxicity, while allowing for a two‐ to sixfold reduction in both the concentration of PNPs as well as the duration of ultrasound. Furthermore, that this reduction minimizes cytotoxicity toward fibroblast cells, while resulting in a 100‐ to 1000‐fold reduction in bacterial concentration, is demonstrated. Abstract : Bacterial biofilm infections often result in refractory conditions such as chronic wounds, requiring aggressive and invasive treatment strategies with high costs and poor patient compliance. A combination treatment of ultrasound and antimicrobial polymeric nanoparticles which rapidly and effectively eradicates bacterial biofilms is reported. Ultrasound treatment enhances the penetration of nanomaterials and the susceptibility of bacteria, resulting in synergistic antibacterial activity.