Pharmacokinetics of lanoconazole in human skin after repeated topical application. Issue 11 (10th July 2022)

• Record Type: Journal Article
• Authors: Imai, Hiromitsu; Hashimoto, Satoru; Ninomiya, Ryo; Luo, Jingna; Wakuda, Hirokazu; Otani, Naoyuki; Inoue, Genta; Amagishi, Hiroaki; Uemura, Naoto
• Is Part Of: Journal of dermatology. Volume 49:Issue 11(2022)
• Page Start: 1118
• Page End: 1123
• Publication Date: 2022-07-10
• Subjects: dermato‐pharmacokinetics -- lanoconazole -- repeated topical application; Dermatology -- Periodicals; Dermatology -- Japan -- Periodicals; Skin -- Diseases -- Periodicals; 616.5005
• DOI: 10.1111/1346-8138.16515
• Languages: English
• ISSNs: 0385-2407

Abstract

Abstract: Drug disposition after topical application to the skin has not been fully elucidated, especially after repeated application. We conducted a clinical trial to evaluate the pharmacokinetics in the stratum corneum of healthy adults after repeated application of lanoconazole cream as a model drug. We applied 25 mg of 1% lanoconazole cream onto the pre‐specified areas on the participants' back once daily for 5 days. The stratum corneum was sampled twice on each study day using a standardized tape‐stripping method, and the amount of lanoconazole contained in the samples was quantified using the tandem mass spectrometry method. The obtained data were used to evaluate lanoconazole pharmacokinetics in the stratum corneum. The amount of lanoconazole in the stratum corneum after once daily repeated administration reached a steady state on day 3, and it was eliminated from the stratum corneum with a half‐life of approximately 11 h after discontinuing application.