Extracellular Vesicles in Tissue Engineering: Biology and Engineered Strategy. Issue 21 (11th September 2022)

• Record Type: Journal Article
• Authors: Pan, Ziyin; Sun, Weiyan; Chen, Yi; Tang, Hai; Lin, Weikang; Chen, Jiafei; Chen, Chang
• Is Part Of: Advanced healthcare materials. Volume 11:Issue 21(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-09-11
• Subjects: bioactive materials -- engineered strategies -- extracellular vesicles -- surface modification -- tissue engineering; Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/adhm.202201384
• Languages: English
• ISSNs: 2192-2640

Abstract

Abstract: Extracellular vesicles (EVs), acting as an important ingredient of intercellular communication through paracrine actions, have gained tremendous attention in the field of tissue engineering (TE). Moreover, these nanosized extracellular particles (30–140 nm) can be incorporated into biomaterials according to different principles to facilitate signal delivery in various regenerative processes directly or indirectly. Bioactive biomaterials as the carrier will extend the retention time and realize the controlled release of EVs, which further enhance their therapeutic efficiency in tissue regeneration. Herein, the basic biological characteristics of EVs are first introduced, and then their outstanding performance in exerting direct impacts on target cells in tissue regeneration as well as indirect effects on promoting angiogenesis and regulating the immune environment, due to specific functional components of EVs (nucleic acid, protein, lipid, etc.), is emphasized. Furthermore, different design ideas for suitable EV‐loaded biomaterials are also demonstrated. In the end, this review also highlights the engineered strategies, which aim at solving the problems related to natural EVs such as highly heterogeneous functions, inadequate tissue targeting capabilities, insufficient yield and scalability, etc., thus promoting the therapeutic pertinence and clinical potential of EV‐based approaches in TE. Abstract : Extracellular vesicles (EVs) have gained tremendous attention in the field of tissue engineering (TE). Moreover, they can be combined with biomaterials according to different principles to facilitate signal delivery in various regenerative processes directly or indirectly. Furthermore, engineered EVs can solve the problems related to natural EVs to promote the therapeutic pertinence and clinical potential of EV‐based approaches in TE.