Formamidation of a wide range of substituted and functionalized amines with CO and a base. Issue 22 (11th October 2022)

• Record Type: Journal Article
• Authors: Zhang, Chunyan; Zhang, Yushuang; Liang, Qianqian; Zhang, Guohui; Yang, Wei; Li, Nanwen; Qin, Guiping; Zhang, Guoying
• Is Part Of: Organic chemistry frontiers. Volume 9:Issue 22(2022)
• Page Start: 6142
• Page End: 6148
• Publication Date: 2022-10-11
• Subjects: Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1039/d2qo01312f
• Languages: English
• ISSNs: 2052-4110

Abstract

Abstract : We have developed a base mediated formamidation of amines with CO under mild conditions, which allows for the synthesis of a wide range of aromatic and aliphatic formamides in high yields and gram amounts in the absence of a transition metal. Abstract : Current methods for preparing formamides are limited by the narrow substrate scope and requirement for harsh reaction conditions. A base-mediated formamidation of amines with CO (<2 bar) under mild conditions was developed, which enabled the synthesis of a wide range of formamides in 61% to 98% yields under transition-metal-free conditions. This provides a useful strategy for generating gram amounts of various aromatic and aliphatic amides.