A carbapenem‐resistant clinical isolate ofAeromonas hydrophilain Japan harbouring an acquired gene encoding GES‐24 β‐lactamase. Issue 11 (November 2018)

• Record Type: Journal Article
• Authors: Uechi, Kohei; Tada, Tatsuya; Sawachi, Yusuke; Hishinuma, Tomomi; Takaesu, Rei; Nakama, Mika; Nakasone, Isamu; Kirikae, Teruo; Fujita, Jiro
• Is Part Of: Journal of medical microbiology. Volume 67:Issue 11(2018)
• Publication Date: 2018-11
• Subjects: carbapenem‐resistant -- carbapenemase -- GES‐24 -- Aeromonas hydrophila; Medical microbiology -- Periodicals; 616.9041
• DOI: 10.1099/jmm.0.000842
• Languages: English
• ISSNs: 0022-2615

Abstract

Abstract : N/A: Several species of Aeromonas produce the enzyme CphA metallo‐β‐lactamase. This study describes an isolate of Aeromonas hydrophila harbouring an acquired gene encoding the carbapenemase GES‐24. This isolate was obtained from an inpatient in Okinawa, Japan, with no apparent record of travelling overseas. The minimum inhibitory concentrations of carbapenems against this isolate were 8 μg ml ‐1 for imipenem and 16 μg ml ‐1 for meropenem. Recombinant GES‐24 hydrolyzed all of the tested β‐lactams, including imipenem and meropenem. The genomic environment surrounding bla GES‐24 was intI1‐bla GES‐24 ‐aac(6′)‐IIc‐qacEdelta1‐sulI‐orfX‐tetR‐tetE . This is the first report of A. hydrophila producing a GES‐type carbapenemase.