Cardiorespiratory Optimal Point Is a Submaximal Exercise Test Variable and a Predictor of Mortality Risk: THE BALL STATE ADULT FITNESS LONGITUDINAL LIFESTYLE STUDY (BALL ST). Issue 6 (7th November 2022)

• Record Type: Journal Article
• Authors: Peterman, James E.; Harber, Matthew P.; Fleenor, Bradley S.; Whaley, Mitchell H.; Araújo, Claudio G.; Kaminsky, Leonard A.
• Is Part Of: Journal of cardiopulmonary rehabilitation and prevention. Volume 42:Issue 6(2022)
• Page Start: E90
• Page End: E96
• Publication Date: 2022-11-07
• Subjects: cardiopulmonary exercise testing -- prognosis -- ventilatory expired gas; Cardiopulmonary system -- Diseases -- Patients -- Rehabilitation -- Periodicals; Cardiopulmonary system -- Diseases -- Prevention -- Periodicals; 616.103
• DOI: 10.1097/HCR.0000000000000711
• Languages: English
• ISSNs: 1932-7501

Abstract

Abstract : This study investigated the relationship between cardiorespiratory optimal point (COP) and all-cause mortality in a cohort of apparently healthy adults. The COP was related to all-cause mortality in apparently healthy males but not in females. These findings suggest that a determination of COP has prognostic utility in males. Abstract : Purpose: The cardiorespiratory optimal point (COP) is the minimum ventilatory equivalent for oxygen. The COP can be determined during a submaximal incremental exercise test. Reflecting the optimal interaction between the respiratory and cardiovascular systems, COP may have prognostic utility. The aim of this investigation was to determine the relationship between COP and all-cause mortality in a cohort of apparently healthy adults. Methods: The sample included 3160 apparently healthy adults (46% females) with a mean age of 44.0 ± 12.5 yr who performed a cardiopulmonary exercise test. Cox proportional hazards models were performed to assess the relationship between COP and mortality risk. Prognostic peak oxygen uptake (V˙o 2peak ) and COP models were compared using the concordance index. Results: There were 558 deaths (31% females) over a follow-up period of 23.0 ± 11.9 yr. For males, all Cox proportional hazards models, including the model adjusted for traditional risk factors and V˙o 2peak, had a positive association with risk for mortality ( P < .05). For females, only the unadjusted COP model was associated with risk for mortality ( P < .05). The concordance index values indicated that unadjusted COP models had lower discrimination compared with unadjusted V˙o 2peak models ( P < .05) and V˙o 2peak did not complement COP models ( P ≥ .13). Conclusions: Cardiorespiratory optimal point is related to all-cause mortality in males but not females. These findings suggest that a determination of COP can have prognostic utility in apparently healthy males aged 18-85 yr, which may be relevant when a maximal exercise test is not feasible or desirable.