Diagnostic Utility of Diffusion-Weighted Imaging and Apparent Diffusion Coefficient for Common Orbital Lesions: A Review. Issue 6 (November 2022)

• Record Type: Journal Article
• Authors: Cameron, Cassie A.; Tong, Jessica Y.; Juniat, Valerie; Patel, Sandy; Selva, Dinesh
• Is Part Of: Ophthalmic plastic and reconstructive surgery. Volume 38:Issue 6(2022)
• Page Start: 515
• Page End: 521
• Publication Date: 2022-11
• Subjects: Eye -- Surgery -- Periodicals; Ophthalmic plastic surgery -- Periodicals; Reconstructive Surgical Procedures -- Periodicals; Ophthalmologic Surgical Procedures -- Periodicals; Ophthalmology -- Periodicals; Surgery -- Periodicals; 617.70592
• DOI: 10.1097/IOP.0000000000002092
• Languages: English
• ISSNs: 0740-9303

Abstract

Abstract : Purpose: To review and summarize the existing literature surrounding the clinical use of diffusion-weighted imaging and apparent diffusion coefficient (ADC) as diagnostic tools in differentiating common orbital lesions. Methods: A systematic literature review on the use of ADC and diffusion-weighted imaging sequences for orbital imaging was performed. Only original research articles that reported ADC values for benign or malignant lesions were included. Results: Malignant orbital tumors have an overall lower mean ADC value than benign masses. Orbital lymphoma is characterized by consistently lower ADC values compared with other malignant orbital masses; a threshold value less than 0.775 × 10 −3 mm 2 /s has been proposed to distinguish orbital lymphoma from other neoplastic and non-neoplastic orbital masses. To differentiate orbital inflammatory disease from lymphoma, an ADC threshold greater than 0.92 × 10 −3 mm 2 /s has been proposed. Conclusions: Orbital masses encompass a host of benign and malignant etiologies and can present a diagnostic challenge on both clinical and radiological assessment. Recent advanced MRI techniques such as diffusion-weighted imaging and ADC can improve the diagnostic specificity for orbital disease, particularly in differentiating benign from malignant lesions and lymphoma from orbital inflammatory disease. Abstract : Diffusion-weighted imaging and apparent diffusion coefficient are advanced magnetic resonance imaging sequences that have a role in characterizing common orbital lesions, including differentiating benign from malignant tumors and lymphoma from orbital inflammatory disease.