Reversal Strategies for Newer Oral Anticoagulants. (2017)

• Record Type: Journal Article
• Authors: Singer, Adam J.; Wilson, Susan
• Is Part Of: AACN advanced critical care. Volume 28:Number 4(2017)
• Publication Date: 2017
• Subjects: management of bleeding event -- nonvitamin K antagonist oral anticoagulant -- NOAC -- anticoagulation -- reversal; Intensive care nursing -- Periodicals; Critical care medicine -- Periodicals; 616.028
• DOI: 10.4037/aacnacc2017744
• Languages: English
• ISSNs: 1559-7768

Abstract

Abstract : N/A: Nonvitamin K antagonist oral anticoagulants have advantages compared with warfarin, but both types of anticoagulants come with uncertainty about how best to manage life‐threatening bleeding events, urgent surgeries, and invasive procedures. Nurse practitioners and physician assistants may need to manage such emergency situations in the critical care setting. Achieving hemostasis quickly is key, and efforts to do so have relied mainly on blood products. Targeted reversal agents are in clinical development and one, idarucizumab, which reverses dabigatran anticoagulation, has been approved. Current options for managing events and urgent procedures in anticoagulated patients are discussed in this article, with a focus on specific reversal agents.