Plasma advanced oxidation products as an additional tool in assessment of post-infarction heart failure. Issue 12 (December 2022)

• Record Type: Journal Article
• Authors: Cvetkovic, Tatjana; Saric, Sandra; Stefanovic, Nikola; Stojiljkovic, Vladana; Djordjevic, Branka; Stojanovic, Dijana; Cvetkovic, Mina; Deljanin Ilic, Marina
• Is Part Of: Journal of international medical research. Volume 50:Issue 12(2022)
• Publication Date: 2022-12
• Subjects: Post-infarction heart failure -- ejection fraction -- advanced oxidation protein products -- oxidative stress; Medicine -- Periodicals; Pharmacology -- Periodicals; 610.5
• DOI: 10.1177/03000605221139711
• Languages: English
• ISSNs: 0300-0605

Abstract

Objective: To define which oxidative stress markers could be used as diagnostic tools in the assessment of post-infarction heart failure (HF). Methods: This observational study enrolled patients with HF that were divided into three subgroups (ejection fraction [EF] ≥ 50%; EF 40–49%; EF < 40%) and age- and sex-matched healthy control subjects. The plasma concentrations of advanced oxidation protein products (AOPP), thiobarbituric acid reactive substances, catalase activity and free thiols were determined in all participants. Results: The study enrolled 81 patients with HF and 68 healthy control subjects. There were significant differences in the values ​​of oxidative stress markers between patients and controls. Oxidative stress parameters did not differ between the subgroups of patients, except for AOPP, which was significantly higher in the EF < 40% group. Univariate and multivariate logistic regression analyses showed an association between AOPP and HF in the EF ≥ 50% group, while receiver operating characteristic (ROC) curve analysis identified a cut-off value of 60.89 µmol/l for AOPP. Conclusions: Based on the ROC curve analysis of AOPP and the higher significance in the multivariate analyses for patients with EF ≥ 50%, these current results suggest that AOPP could be a useful additional tool in the assessment of post-infarction HF.