Mixed‐Metal MOF‐Derived Hollow Porous Nanocomposite for Trimodality Imaging Guided Reactive Oxygen Species‐Augmented Synergistic Therapy. (26th June 2021)

• Record Type: Journal Article
• Authors: Cheng, Yue; Wen, Cong; Sun, Yi‐Qing; Yu, Hua; Yin, Xue‐Bo
• Is Part Of: Advanced functional materials. Volume 31:Number 37(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-06-26
• Subjects: hollow structures -- metal‐organic frameworks -- synergistic therapies -- trimodality imaging -- tumor microenvironment; Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adfm.202104378
• Languages: English
• ISSNs: 1616-301X

Abstract

Abstract: Here an excellent trimodality imaging‐guided synergistic photothermal therapy (PTT)/photodynamic therapy (PDT)/chemodynamic therapy (CDT) is proposed. To this end, a mixed‐metal Cu/Zn‐metal‐organic framework (MOF) is first assembled at room temperature on a nano‐scale. Interestingly, heating the MOF results in a Cu +/2+ ‐coexisting hollow porous structure. Subsequent heating treatment is used to integrate Mn 2+ and MnO2 in the presence of manganese(II) acetylacetonate. The hollow composite achieves efficient loading of a photosensitizer, indocyanine green (ICG). Under laser irradiation, the aggregated ICG achieves photothermal imaging and PTT. Once released in the tumor site, ICG exhibits fluorescence imaging and PDT capacity. Cu + /Mn 2+ ions perform Fenton‐like reaction with H2 O2 to produce cytotoxic OH for the enhanced CDT. Cu 2+ /MnO2 scavenge glutathione to improve the reactive oxygen species‐based therapy, while the formed Mn 2+ ions enable "turn on" magnetic resonance imaging. Significantly, O2 is produced from the catalytic decomposition of endogenous H2 O2 to improve ICG‐mediated PDT. Moreover, photothermal‐induced local hyperthermia accelerates OH generation to enhance CDT. This synergistic drug‐free antitumor strategy realizes high treatment efficacy and low side effects on normal tissues. Thus, this mixed‐metal MOF is an efficient strategy to realize hollow structures for multi‐function integration to improve therapeutic capacity. Abstract : A mixed‐metal metal‐organic framework strategy is proposed to form a hollow structure, integrating mixed‐metals with mixed‐valences, and loading indocyanine green. The composite enables photothermal/magnetic resonance/fluorescence imaging‐guided photothermal therapy, photodynamic therapy, and chemodynamic therapy. High therapeutic efficiency and negligible side effects are realized as non‐drug treatment.