Catastrophic Neurological Complications in 2 Patients With Sickle Cell Disease and COVID-19. (July 2022)

• Record Type: Journal Article
• Authors: Clarke, Karen; Benameur, Karima; Wiley, Zanthia; Shin, Yoo Mee; Moussa, Mohamad; El Rassi, Fuad; McLemore, Morgan
• Is Part Of: Journal of investigative medicine high impact case reports. Volume 10(2022)
• Publication Date: 2022-07
• Subjects: COVID-19 -- sickle cell -- neurological complications; Internal medicine -- Periodicals; Medical care -- Periodicals; 616.005
• DOI: 10.1177/23247096221111778
• Languages: English
• ISSNs: 2324-7096

Abstract

Severe acute respiratory syndrome coronavirus (SARS-CoV-2) infection is commonly associated with neurological complications. Patients with sickle cell disease are at increased risk of developing neurologic complications throughout their lifetimes and often have underlying cardiopulmonary comorbidities that may predispose them to poor outcomes during serious infections. In this case series, we describe 2 patients with sickle cell disease who developed devastating neurologic complications following SARS-CoV-2 infection, which ultimately led to brain edema and death. We highlight the unusual manifestations of coronavirus disease 2019 in patients with sickle cell disease and address the risk of these patients to develop catastrophic neurologic injury due to COVID-19, if not recognized promptly.