Generation of HBsAg‐reactive T‐ and B‐cells following HBV vaccination in serological non‐responders under hemodialysis treatment. Issue 5 (9th February 2021)

• Record Type: Journal Article
• Authors: Roch, Toralf; Giesecke‐Thiel, Claudia; Blazquez‐Navarro, Arturo; Wehler, Patrizia; Thieme, Constantin J.; Juelke, Kerstin; Grütz, Gerald; Hörstrup, Jan; Witzke, Oliver; Dittmer, Ulf; Stervbo, Ulrik; Reinke, Petra; Westhoff, Timm H.; Babel, Nina
• Is Part Of: European journal of immunology. Volume 51:Issue 5(2021)
• Page Start: 1278
• Page End: 1281
• Publication Date: 2021-02-09
• Subjects: antigen‐specific B cells -- anti‐HBsAg titer -- hepatitis B virus -- renal diseases -- T cells; Immunology -- Periodicals; 616.079
• DOI: 10.1002/eji.202048756
• Languages: English
• ISSNs: 0014-2980

Abstract

Abstract : HBV vaccination is recommend for hemodialysis patients, but only 50–60% of the patients show seroconversion. HBV vaccine‐induced generation of HBV reactive T and B cells could be detected regardless of their capacity to mount a serological response, indicating that patients without seroconversion are potentially protected by their HBV‐reactive T cell pool.