Injectable platelet‐rich fibrin for perioral rejuvenation as assessed by 3D lip volume imaging. (24th September 2021)

• Record Type: Journal Article
• Authors: Hamid, Omar; Quinlan, Daniel J.; Seemann, Rudolf; Hassan, Haidar
• Is Part Of: Journal of cosmetic dermatology. Volume 20:Number 10(2021)
• Page Start: 3270
• Page End: 3277
• Publication Date: 2021-09-24
• Subjects: FACE‐Q -- facial rejuvenation -- lips -- platelets -- PRF; Skin -- Diseases -- Treatment -- Periodicals; Lasers in surgery -- Periodicals; Skin -- Pathophysiology -- Periodicals; Surgery, Plastic -- Periodicals; 616.5
• DOI: 10.1111/jocd.14394
• Languages: English
• ISSNs: 1473-2130

Abstract

Abstract: Background: Various injectable autologous platelet aggregate preparations have been developed and used for facial rejuvenation. Limited evidence exists for the use of these for augmentation of the lip. Objectives: This prospective, uncontrolled, single‐center study evaluated the qualitative and quantitative effects of an injectable platelet‐rich fibrin preparation (known as i‐PRF+) for lip augmentation. Patients/methods: PRF ® PROCESS system technology was used to prepare i‐PRF+ supernatant. Ten healthy females were included in the study and received a single intradermal injection of i‐PRF+ in the upper and lower lips (5 ml in each quadrant, total ~2 ml). Participants were followed for 3 months post‐procedure. The efficacy of the procedure was assessed qualitatively by a subjective patient‐reported outcome (FACE‐Q) assessment and quantitatively by objective 3D skin surface volume analysis (ProFace ® ) at baseline and after 3 months. Results: FACE‐Q scales that measure satisfaction with skin and lip showed a statistically significant improvement from baseline ( p = 0.04 and p = 0.02, respectively). Satisfaction with lip lines showed a numerical improvement with mean total scores for adverse effect scales related to the skin and lips reduced at 2 weeks post‐procedure ( p = 0.03 and p = 0.13, respectively). Overall lip volume at 3‐month follow‐up was unchanged ( p = 0.11). The treatment was well tolerated with only minor adverse effects. Conclusions: A single session of i‐PRF+ injections resulted in significant lip rejuvenation at 3‐month follow‐up, shown by improved patient‐reported outcome measure. No significant change in lip volume was observed.