Association of Acute Perioperative Myocardial Injury With All-Cause Mortality Within 90 Days After Hip Fracture Repair in the Elderly: A Prospective Study. (11th January 2022)

• Record Type: Journal Article
• Authors: Wang, Lei; Cai, Meng; Li, Xiaoying; Deng, Xiaohui; Xue, Qiang; Zhou, Li; Yang, Minghui
• Is Part Of: Geriatric orthopaedic surgery & rehabilitation. Volume 13(2022)
• Publication Date: 2022-01-11
• Subjects: acute perioperative myocardial injury -- elderly population -- hip fracture -- 90-day all-cause mortality -- myocardial injury and mortality; Older people -- Surgery -- Periodicals; Orthopedic surgery -- Periodicals; Geriatrics -- Rehabilitation -- Periodicals; 617.97
• DOI: 10.1177/21514593211070129
• Languages: English
• ISSNs: 2151-4585

Abstract

Introduction: It remains unclear whether acute perioperative myocardial injury (APMI) increases mortality in the elderly. This study aimed to investigate APMI's association with mortality within 90 days after hip fracture repair in elderly patients. Materials and Methods: This prospective study enrolled elderly patients admitted to the department of Traumatology and Orthopaedics in XXX Hospital, who underwent surgery in 2018–2019 with a 90-day follow-up. According to survival status within 90 days, survival and death groups were constituted. Clinical, demographic, and laboratory indicators and 90-day mortality post-surgery were recorded. APMI's association with 90-day mortality post-surgery was analyzed by logistic regression. Results: Totally 248 participants were enrolled, including 224 and 24 in the survival and death groups, respectively, for a mortality rate of 9.7%. Compared with surviving individuals, the death group was older [81 (75–86) vs 87 (82–89) years], and had higher incidence rates of APMI (24.6% vs 58.3%), intertrochanteric fractures (41.1% vs 62.5%), preoperative atrial fibrillation (8.9% vs 29.2%), and dementia (73.7% vs 95.8%) (all P< .05). They also showed higher pre-injury frail scale scores [1 (0–2) vs 3 (1–4)] and Nottingham hip fracture scores (NHFSs) [4 (4–5) vs 6.5 (5–7)], lower Glomerular filtration [62 (46.1–78.6) vs 44.37 (35–61.92) ml/min], and reduced odds of glomerular filtration rate <60 mL/min (75.0% vs 46.9%) (all P < .05). APMI (OR = 3.294, 95% CI: 1.217–8.913) and NHFS (OR = 2.089, 95% CI: 1.353–3.225) independently predicted 90-day mortality post-surgery (all P< .05). Conclusions: APMI is associated with increased mortality risk within 90 days after hip fracture repair in elderly patients.